P3635
5β-Pregnane-3α,20α-diol glucuronide
≥98.00% (TLC), powder, progesterone metabolite
别名:
P3G, PDG, Pn3-G, Pregnanediol-3a-glucuronide, Pregnanediol-glucuronide, 3α,20α-Dihydroxy-5β-pregnane 3-glucuronide
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关于此项目
经验公式（希尔记法）:
C27H44O8
化学文摘社编号:
分子量:
496.63
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
5β-Pregnane-3α,20α-diol glucuronide,
SMILES string
CC(O)C1CCC2C3CCC4CC(CCC4(C)C3CCC12C)OC5OC(C(O)C(O)C5O)C(O)=O
InChI key
ZFFFJLDTCLJDHL-UHFFFAOYSA-N
InChI
1S/C27H44O8/c1-13(28)17-6-7-18-16-5-4-14-12-15(8-10-26(14,2)19(16)9-11-27(17,18)3)34-25-22(31)20(29)21(30)23(35-25)24(32)33/h13-23,25,28-31H,4-12H2,1-3H3,(H,32,33)
sterility
non-sterile
assay
≥98.00% (TLC)
form
powder
technique(s)
enzyme immunoassay: suitable
solubility
ethanol: 20 mg/mL, clear, colorless
shipped in
ambient
storage temp.
−20°C
Quality Level
General description
5β-Pregnane-3α,20α-diol glucuronide is a progesterone metabolite predominant in urine, during pregnancy. Presence of 5β-Pregnane-3α,20α-diol glucuronide in the urine indicates pregnancy, but it might also account for pseudopregnancy. It is useful in predicting the delivery time/end of pseudopregnancy.
Urinary pregnanediol glucuronide (PdG) seems to serve as an effective clinical marker for monitoring progesterone supplementation. PdG, along with other urinary metabolites such as luteinizing hormone (LH), follicle stimulating hormone (FSH), and estrone glucuronide (ElG), exhibit a strong association with ovarian excretion rates and demonstrate a high correlation with serum reproductive hormones. As a result, they can be used interchangeably to effectively monitor ovarian steroidogenesis.
Application
5β-Pregnane-3α,20α-diol glucuronide has been used in a cross-sectional analysis of hormone levels. It has also been used as a standard to measure estradiol-17β, pregnanediol-glucuronide (PdG) by a double-antibody enzyme immunoassay.
5β-Pregnane-3α,20α-diol glucuronide has been used in steroid enzyme immunoassay.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
涉药品监管产品
此项目有
Kathleen A O'Connor et al.
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Detailed characterization of estrogen dynamics during the transition to menopause is an important step toward understanding its potential implications for reproductive cancers developing in the transition years. We conducted a 5-year prospective study of endogenous levels of total and unopposed
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Matias-Garcia PR, et al.
Methods in Molecular Biology (2018)
Endocrine pregnancy monitoring in the two-toed sloth (Choloepus didactylus):?Pregnant or not pregnant?
Troll S, et al.
Theriogenology, 84(1), 137-144 (2015)
Susanna J Park et al.
Fertility and sterility, 88(3), 684-690 (2007-04-17)
To define characteristics of the luteinizing hormone (LH) surge in urine. Observational study. Academic center. 46 women aged 20 to 35 years with regular menstrual cycles. Collected first morning urine daily, throughout one menstrual cycle. Urinary LH, follicle-stimulating hormone (FSH)
Chest Pain with Normal Coronary Arteries: A Multidisciplinary Approach, 323-323 (2013)
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