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Merck
CN

P3905

pGlu-His-Pro

≥97% (TLC)

别名:

TRH, Thyrotropin releasing hormone

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关于此项目

经验公式(希尔记法):
C16H21N5O5
化学文摘社编号:
分子量:
363.37
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
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SMILES string

OC(=O)C1CCCN1C(=O)C(Cc2cnc[nH]2)NC(=O)C3CCC(=O)N3

assay

≥97% (TLC)

storage temp.

−20°C

Gene Information

mouse ... Trhr(22045)

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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历史批次信息供参考:

分析证书(COA)

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E C Griffiths et al.
Molecular and cellular endocrinology, 18(1), 59-67 (1980-04-01)
Specific radioimmunoassays for thyrotrophin-releasing hormone (TRH) and deamido-TRH (TRH-OH) were used to investigate the inactivation of TRH by subcellular fractions from rat hypothalamus. TRH-OH was rapidly formed from TRH by an amidase present only in the supernatant fraction at an
J López-Barneo et al.
Proceedings of the National Academy of Sciences of the United States of America, 87(20), 8150-8154 (1990-10-01)
The interaction of thyrotropin-releasing hormone (TRH) and its physiological metabolite TRH-OH with Na+ channels was studied in enzymatically dissociated guinea pig septal neurons by using the whole-cell variant of the patch-clamp technique. In about 60% of the cells tested, the
Concentrations of thyrotropin-releasing hormone (TRH) and deamido-TRH, and TRH deamidase activity in brain.
C H Emerson et al.
Endocrinology, 107(2), 443-449 (1980-08-01)
C G Scanes et al.
Neuroendocrinology, 40(1), 33-38 (1985-01-01)
Thyrotropin-releasing hormone (TRH) stimulated in vivo growth hormone (GH) release in conscious and anesthetized young domestic fowl. The administration of the presumed metabolites of TRH, deamido-TRH (TRH-OH) and histidyl-proline diketopiperazine (HPD), was followed by small but significant (p less than
V Reny-Palasse et al.
Pain, 30(2), 259-269 (1987-08-01)
The antinociceptive action of the 2 main metabolites of thyrotropin-releasing hormone (TRH), pyroglutamyl-histidyl-proline (TRH-OH) and histidyl-proline-diketopiperazine or cyclo(His-Pro), were studied using mechanical (Haffner's test) and chemical (phenyl-p-benzoquinone writhing test) stimuli. TRH has previously been shown to be active against both

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