P3998
PGL-135 hydrochloride monohydrate
≥98% (HPLC), solid
别名:
2-Amino-4,7-dimethyl-6-hydroxybenzothiazole hydrochloride monohydrate
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关于此项目
经验公式（希尔记法）:
C9H10N2OS · HCl · H2O
化学文摘社编号:
分子量:
248.73
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI key
AIOZIUZKTGVUHB-UHFFFAOYSA-N
SMILES string
Cl[H].Cc1cc(O)c(C)c2sc(N)nc12
InChI
1S/C9H10N2OS.ClH/c1-4-3-6(12)5(2)8-7(4)11-9(10)13-8;/h3,12H,1-2H3,(H2,10,11);1H
assay
≥98% (HPLC)
form
solid
storage condition
desiccated, protect from light, under inert gas
color
off-white
solubility
DMSO: >5 mg/mL, H2O: insoluble
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
Cell-permeable polyglutamine aggregation inhibitor
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
新产品
此项目有
Volker Heiser et al.
Proceedings of the National Academy of Sciences of the United States of America, 99 Suppl 4, 16400-16406 (2002-08-30)
Preventing the formation of insoluble polyglutamine containing protein aggregates in neurons may represent an attractive therapeutic strategy to ameliorate Huntington's disease (HD). Therefore, the ability to screen for small molecules that suppress the self-assembly of huntingtin would have potential clinical
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