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Merck
CN

P4153

Prednisolone 21-hemisuccinate sodium salt

≥90%, powder

别名:

Δ1-Hydrocortisone 21-hemisuccinate, 1,4-Pregnadiene-11β,17,21-triol-3,20-dione 21-hemisuccinate, 11β,17α,21-Trihydroxy-1,4-pregnadiene-3,20-dione 21-hemisuccinate

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关于此项目

线性分子式:
C25H31O8Na
化学文摘社编号:
1715-33-9
分子量:
482.50
NACRES:
NA.77
PubChem Substance ID:
24898507
UNSPSC Code:
51111800
EC Number:
216-995-1
MDL number:
MFCD00070045

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InChI key

HLHQSPQPHMOTMP-FKIWUUNWSA-N

InChI

1S/C25H32O8.Na.H/c1-23-9-7-15(26)11-14(23)3-4-16-17-8-10-25(32,24(17,2)12-18(27)22(16)23)19(28)13-33-21(31)6-5-20(29)30;;/h7,9,11,16-18,22,27,32H,3-6,8,10,12-13H2,1-2H3,(H,29,30);;/t16-,17-,18-,22+,23-,24-,25-;;/m0../s1

SMILES string

[Na].[H][C@@]12CCC3=CC(=O)C=C[C@]3(C)[C@@]1([H])[C@@H](O)C[C@@]4(C)[C@@]2([H])CC[C@]4(O)C(=O)COC(=O)CCC(O)=O

biological source

synthetic

sterility

non-sterile

assay

≥90%

form

powder

shipped in

ambient

storage temp.

−20°C

Quality Level

200

color

, White to Light Yellow to Light Beige

solubility

hot water: 50 mg/mL, clear to very slightly hazy (Colorless to Light Yellow to Light Brown-Yellow)

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pictograms

Health hazard
GHS08

signalword

Danger

hcodes

H360D

Hazard Classifications

Repr. 1B

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCM7070
BCBW2082
BCBB6186V
BCBB6186
077K1581

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Ellen C La Heij et al.
American journal of ophthalmology, 143(1), 176-178 (2006-12-26)
To evaluate the six-month results of patients treated with intravitreal prednisolone sodium succinate injections for persistent diabetic macular edema. Retrospective, noncontrolled, clinical case series. Nineteen eyes had intravitreal injections with prednisolone sodium succinate. Need for retreatment was based on fluorescein
Mareike Probst et al.
International journal of pharmaceutics, 532(1), 519-527 (2017-09-25)
The number of intramuscularly applied dosage forms has been continuously increasing during the last decades. However, up to date no in vitro dissolution test method for parenteral dosage forms has been described in the Ph. Eur. or USP. It was
Hiraku Onishi et al.
International journal of pharmaceutics, 410(1-2), 17-22 (2011-03-15)
Recently, many people have developed rheumatoid arthritis (RA), and prednisolone (PD) is often used for treatment; however, long use and a large dose of PD can cause toxic side effects. In this study, in order to enhance the therapeutic effects
Tomofumi Ogoshi et al.
Modern rheumatology, 18(6), 552-561 (2008-07-24)
The influence of glucocorticoid (GC) on bone in rats at different ages was investigated in order to provide insight into human glucocorticoid induced osteoporosis (GCOP). Three-, 6-, and 12-month-old female Wistar rats were divided into four groups: Zero-time control (ZT)
E Mabuchi et al.
The British journal of dermatology, 157(3), 596-598 (2007-06-29)
Non-Herlitz junctional epidermolysis bullosa (JEB-nH), a nonlethal variant of junctional epidermolysis bullosa (JEB), is an autosomal recessive disorder characterized by separation of the dermal-epidermal junction. JEB-nH is caused by mutations in several genes and lack of the COL17A1 gene product
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