P4157
苯丙氨酸-精氨酸 β-萘胺 二盐酸盐
cathepsin substrate, fluorogenic, ≥98% (TLC), powder
别名:
PAβN
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关于此项目
经验公式（希尔记法）:
C25H30N6O2 · 2HCl
化学文摘社编号:
分子量:
519.47
UNSPSC Code:
12352204
PubChem Substance ID:
NACRES:
NA.32
MDL number:
产品名称
苯丙氨酸-精氨酸 β-萘胺 二盐酸盐, cathepsin substrate
form
powder
SMILES string
Cl.NC(Cc1ccccc1)C(=O)NC(CCCNC(N)=N)C(=O)Nc2ccc3ccccc3c2
InChI
1S/C25H30N6O2.ClH/c26-21(15-17-7-2-1-3-8-17)23(32)31-22(11-6-14-29-25(27)28)24(33)30-20-13-12-18-9-4-5-10-19(18)16-20;/h1-5,7-10,12-13,16,21-22H,6,11,14-15,26H2,(H,30,33)(H,31,32)(H4,27,28,29);1H
InChI key
ZMTAZQYLEGNUTJ-UHFFFAOYSA-N
assay
≥98% (TLC)
solubility
water: 50 mg/mL, clear, colorless to faintly yellow
storage temp.
−20°C
Quality Level
Application
Phe-Arg-萘酰胺二盐酸盐用于评估外排泵对抗菌素耐药性的贡献。在存在外排泵抑制剂的条件下，它还用于最小抑菌浓度测试。
General description
Phe-Arg β-萘酰胺，一种拟肽化合物， 是一种外排泵抑制剂（EPI）。它可作用于革兰氏阴性细菌的主要多药耐药性外向转运蛋白。Phe-Arg-萘酰胺可在铜绿假单胞菌中降低氟喹诺酮类药物的耐药性。
二肽基氨肽酶I（组织蛋白酶C）的底物。
Packaging
无底玻璃瓶。内含物在插入的融合锥体内。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Fluoroquinolone resistance mechanisms in multidrug-resistant Escherichia coli isolated from extraintestinal infections in dogs
Gibson JS, et al.
Veterinary Microbiology, 146(1-2), 161-166 (2010)
Commonality among fluoroquinolone-resistant sequence type ST131 extraintestinal Escherichia coli isolates from humans and companion animals in Australia
Platell JL, et al.
Antimicrobial Agents and Chemotherapy, 55(8), 3782-3787 (2011)
Proof of an Outer Membrane Target of the Efflux Inhibitor Phe-Arg-beta-Naphthylamide from Random Mutagenesis
Schuster S, et al.
Molecules (Basel), 24(3), 470-470 (2019)
Nagakumar Bharatham et al.
Nature communications, 12(1), 5400-5400 (2021-09-15)
OqxB is an RND (Resistance-Nodulation-Division) efflux pump that has emerged as a factor contributing to the antibiotic resistance in Klebsiella pneumoniae. OqxB underwent horizontal gene transfer and is now seen in other Gram-negative bacterial pathogens including Escherichia coli, Enterobacter cloacae
Christopher Concha et al.
Microorganisms, 7(12) (2019-12-19)
Despite their great importance for human therapy, quinolones are still used in Chilean salmon farming, with flumequine and oxolinic acid currently approved for use in this industry. The aim of this study was to improve our knowledge of the mechanisms
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