P4194
DL-苏式-1-苯基-2-棕榈酰氨基-3-吗啉-1-丙醇
98%
别名:
(±)-PPMP
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关于此项目
经验公式(希尔记法):
C29H50N2O3 · HCl
化学文摘社编号:
分子量:
511.18
MDL编号:
UNSPSC代码:
12352211
PubChem化学物质编号:
NACRES:
NA.25
质量水平
方案
98%
表单
powder
脂质类型
phosphoglycerides
储存温度
2-8°C
SMILES字符串
CCCCCCCCCCCCCCCC(=O)N[C@H](CN1CCOCC1)[C@H](O)c2ccccc2
InChI
1S/C29H50N2O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-17-20-28(32)30-27(25-31-21-23-34-24-22-31)29(33)26-18-15-14-16-19-26/h14-16,18-19,27,29,33H,2-13,17,20-25H2,1H3,(H,30,32)/t27-,29-/m1/s1
InChI key
OFBANDBMHLEMFA-XRKRLSELSA-N
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Virginia Sara Grancieri do Amaral et al.
International journal of molecular sciences, 21(8) (2020-04-16)
Psd1 is a pea plant defensin which can be actively expressed in Pichia pastoris and shows broad antifungal activity. This activity is dependent on fungal membrane glucosylceramide (GlcCer), which is also important for its internalization, nuclear localization, and endoreduplication. Certain
A Abe et al.
Journal of biochemistry, 111(2), 191-196 (1992-02-01)
An inhibitor of glucosylceramide (GlcCer) synthase, 1-phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP), has been reported to deplete cells and mice of their glucosphingolipids. This inhibitor has proved useful for the elucidation of the many functions of this lipid family [reviewed by Radin, N.S. &
D Johansson et al.
British journal of cancer, 102(2), 383-391 (2009-12-17)
A major problem with cisplatin treatment is the development of acquired-drug resistance of the tumour cells. Verotoxin-1 (VT-1) exerts its cytotoxicity by targeting the membrane glycolipid globotriasosylceramide (Gb3), a molecule associated with drug resistance. Cisplatin- and VT-1-induced apoptosis involves mitogen-activated
Dorothee Gramatzki et al.
PloS one, 8(5), e63527-e63527 (2013-05-15)
Resistance to genotoxic therapy is a characteristic feature of glioma cells. Acid sphingomyelinase (ASM) hydrolyzes sphingomyelin to ceramide and glucosylceramide synthase (GCS) catalyzes ceramide metabolism. Increased ceramide levels have been suggested to enhance chemotherapy-induced death of cancer cells. Microarray and
Kelly Drews et al.
PloS one, 15(2), e0228735-e0228735 (2020-02-08)
Influenza virus is an enveloped virus wrapped in a lipid bilayer derived from the host cell plasma membrane. Infection by influenza virus is dependent on these host cell lipids, which include sphingolipids. Here we examined the role of the sphingolipid
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