P4359
吡菲他林-α
≥95% (HPLC), p53-mediated apoptosis inhibitor, powder
别名:
2-（2-亚氨基-4,5,6,7-四氢苯并噻唑-3-基）-1- p -托烷酮 氢溴酸盐, PFT-α
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关于此项目
线性分子式:
C16H18N2OS·HBr
CAS Number:
分子量:
367.30
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
Product Name
吡菲他林-α, ≥95% (HPLC), powder
质量水平
方案
≥95% (HPLC)
表单
powder
储存条件
protect from light
颜色
off-white
mp
192.1-192.5 °C (lit.)
溶解性
DMSO: 20 mg/mL
运输
wet ice
储存温度
−20°C
SMILES字符串
Br[H].Cc1ccc(cc1)C(=O)CN2C(=N)SC3=C2CCCC3
InChI
1S/C16H18N2OS.BrH/c1-11-6-8-12(9-7-11)14(19)10-18-13-4-2-3-5-15(13)20-16(18)17;/h6-9,17H,2-5,10H2,1H3;1H
InChI key
HAGVCKULCLQGRF-UHFFFAOYSA-N
相关类别
应用
吡菲他林-α已用于：
- 研究特异性 p53 抑制剂对短暂性全脑缺血 (tGCI) 后 p53 上调的凋亡调节因子 (PUMA) 表达的影响
- 作为 p53 抑制剂处理 PA1 细胞
- 作为肿瘤蛋白 p53 (TRP53) 抑制剂，处理小鼠肺上皮-12 (MLE-12) 细胞
生化/生理作用
吡菲他林-α是 p53 介导的细胞凋亡和 p53 依赖性基因转录如细胞周期蛋白 G、p21/waf1 和 mdm2 表达的可逆性抑制剂。吡菲他林-α在遗传毒性应激（如 UV 照射）和细胞毒性化合物（包括多柔比星、依托泊苷、紫杉醇和胞嘧啶-β-D-阿拉伯呋喃糖苷）处理后增强细胞存活。吡菲他林-α保护小鼠免受致死性全身 γ-辐射，且不增加癌症发病率。这种保护作用在 p53 缺失的小鼠或 p53 基因显性负突变体表达的细胞中没有观察到。p53 缺陷细胞系中 p53 的瞬时表达赋予保护作用。
特点和优势
该化合物是细胞凋亡研究的特色产品。点击此处发现更多特色细胞凋亡产品。在sigma.com/discover-bsm了解更多关于其他研究领域的生物活性小分子。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
E A Komarova et al.
Biochemistry. Biokhimiia, 65(1), 41-48 (2000-03-07)
The p53 protein is traditionally believed to be a tumor suppressor. Activation of p53-dependent apoptosis in response to damage to cell DNA provides for the elimination of possible tumor cell precursors. However, in some cases the activity of p53 can
Ahmed Malki et al.
Bioorganic chemistry, 72, 57-63 (2017-04-04)
Small molecules that can target human cancers have been highly sought to increase the anticancer efficacy, the present work describes the design and synthesis of novel series of five quinuclidinone derivatives (2a-2e). Their anticancer activities were investigated against breast cancer
Inhibition of regulatory-associated protein of mechanistic target of rapamycin prevents hyperoxia-induced lung injury by enhancing autophagy and reducing apoptosis in neonatal mice
Sureshbabu A, et al.
American Journal of Respiratory Cell and Molecular Biology, 55(5), 722-735 (2016)
Potential role of PUMA in delayed death of hippocampal CA1 neurons after transient global cerebral ischemia
Niizuma K, et al.
Stroke, 40(2), 618-625 (2009)
Jiangli Zheng et al.
Biochemical and biophysical research communications, 503(2), 1108-1114 (2018-06-27)
Cervical cancer is a leading severe malignancy throughout the world. Though various pathologies associated with cervical cancer progression have been demonstrated, further study is still necessary to reveal the tumorigenesis of cervical cancer. The protein histidine phosphatase LHPP is reported
商品
Apoptosis regulation involves multiple pathways and molecules for cellular homeostasis.
Cell cycle phases (G1, S, G2, M) regulate cell growth, DNA replication, and division in proliferating cells.
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