P4394
顺铂
≥99.99% (trace metal analysis), crystalline, macrophage activator
别名:
顺-二氯二氨基铂(II), 顺式-二胺二氯铂, 顺氯氨铂
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关于此项目
线性分子式:
Pt(NH3)2Cl2
化学文摘社编号:
分子量:
300.05
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
239-733-8
MDL number:
Form:
crystalline
Quality level:
Application
顺-二氨基铂(II)二氯化物已用于：
- 耳蜗外植体细胞的活力测量
- 抑制卵巢癌细胞系中的细胞增殖和化学敏感性
- 口服鳞状细胞癌中MTT [3-(4,5-二甲基噻唑-2-基)-2,5-二苯基四唑溴化物]细胞活力检测
Biochem/physiol Actions
强效的铂基抗肿瘤剂。与 DNA 二核苷酸 d(pGpG) 形成细胞毒性加合物，诱导链内交联。
有效的化学免疫治疗药物; 通过激活巨噬细胞和免疫系统的其他细胞来刺激免疫反应。顺铂处理的巨噬细胞在体外显示出增强的抗原呈递功能。治疗增加了巨噬细胞中NF-κB的含量和易位。顺铂的作用受激酶、磷酸酶和Ca2+/钙调蛋白的调节。与DNA二核苷酸d（pGpG）形成细胞毒性加合物，诱导链内交联。
Features and Benefits
该化合物是细胞凋亡研究的特色产品。点击此处以了解更多的细胞凋亡特色产品。可访问sigma.com/discover-bsm了解更多关于用于其他研究领域生物活性小分子。
Preparation Note
本品室温保存。密封保存于通风良好处。干燥。详见安全数据说明书(Safety Data Sheet)。
signalword
Danger
target_organs
Respiratory system
存储类别
6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Hazard Classifications
Acute Tox. 2 Oral - Carc. 1B - Eye Irrit. 2 - Muta. 1B - Repr. 1B - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
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商品
Cell cycle phases (G1, S, G2, M) regulate cell growth, DNA replication, and division in proliferating cells.
Apoptosis regulation involves multiple pathways and molecules for cellular homeostasis.
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| P4394-100MG | 04061835558339 |
| P4394-1G | 04061834374503 |
| P4394-250MG | 04061834374510 |
| P4394-25MG | 04061834374527 |
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