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P4458

青链霉素

Name: 青链霉素
Brand: SIGMA

liquid, non-animal origin, suitable for cell culture, BioReagent

别名:

青霉素-链霉素

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关于此项目

UNSPSC Code:

12352207

NACRES:

NA.76

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产品名称

青链霉素, Solution Stabilized, with 5,000 units penicillin and 5mg streptomycin/mL, 0.1 μm filtered, BioReagent, suitable for cell culture

Quality Level

300

sterility

0.1 μm filtered

product line

BioReagent

form

liquid

concentration

50 ×

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

mode of action

cell wall synthesis | interferes, protein synthesis | interferes

shipped in

dry ice

storage temp.

−20°C

SMILES string

CC1(C)S[C@@H]2[C@H](NC(=O)Cc3ccccc3)C(=O)N2[C@H]1C(O)=O.CNC[C@H]4[C@H](O)[C@@H](O)[C@H](CCO)O[C@H]4O[C@H]5[C@@H](O[C@@H](C)C5(O)C=O)O[C@H]6[C@H](O)[C@@H](O)[C@H](NC(N)=N)[C@@H](O)[C@@H]6NC(N)=N

InChI

1S/C23H43N7O12.C16H18N2O4S/c1-7-23(38,6-32)18(42-19-8(5-28-2)12(33)13(34)9(40-19)3-4-31)20(39-7)41-17-11(30-22(26)27)14(35)10(29-21(24)25)15(36)16(17)37;1-16(2)12(15(21)22)18-13(20)11(14(18)23-16)17-10(19)8-9-6-4-3-5-7-9/h6-20,28,31,33-38H,3-5H2,1-2H3,(H4,24,25,29)(H4,26,27,30);3-7,11-12,14H,8H2,1-2H3,(H,17,19)(H,21,22)/t7-,8-,9-,10+,11-,12-,13-,14+,15-,16+,17+,18-,19-,20-,23+;11-,12+,14-/m01/s1

InChI key

KMOOCZWLFBSQCW-XFOLRDBHSA-N

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General description

Penicillin, a β-lactam antibiotic is extremely active towards bacteria. Penicillins are also termed as penams. It is naturally occurring and has a bicyclic skeleton. Streptomycin is a pseudotrisaccharide. It comprises of a monosubstituted aminocyclitol.

Application

Penicillin-Streptomycin has been used:

as a supplement in Dulbecco′s modified Eagle′s medium (DMEM) to maintain the Huh7 liver hepatoma cell line
as a supplement in Roswell park memorial institute-1640 (RPMI) medium to maintain mouse lymphoma YAC-1 cells
as a component in minimum essential medium Eagle to treat individual mouse spleens for the preparation of splenocytes
as a supplement in FMX-8 complete medium to culture Chinese hamster ovary cells

Recommended for use in cell culture media at 20 ml/L.

Biochem/physiol Actions

Penicillins can prevent the synthesis of bacterial cell wall. This antibiotic can be used in the treatment of skin and urinary tract infections, upper and lower respiratory infections, and endocarditis. Streptomycin can block Mycobacterium tuberculosis in vitro. Streptomycin inhibits prokaryote protein synthesis by preventing the transition from initiation complex to chain-elongating ribosome, causing miscoding.

Other Notes

20ml,100ml

Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

This product is formulated to contain 5,000 units penicillin and 5 mg streptomycin/mL solubilized in a proprietary citrate buffer.

存储类别

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000532786

0000510647

0000510646

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Aminoglycosides Antibiotics

Comprehensive Medicinal Chemistry II, 7, 629-652 (2007)

Streptomyces-derived quorum-sensing systems engineered for adjustable transgene expression in mammalian cells and mice

Weber W, et al.

Nucleic Acids Research, 31(14), e71-e71 (2003)

Effect of Lactobacillus brevis KB290 on the cell-mediated cytotoxic activity of mouse splenocytes: a DNA microarray analysis

Fukui Y, et al.

The British Journal of Nutrition, 110(9), 1617-1629 (2013)

Antibiotic drugs targeting bacterial RNAs.

Weiling Hong et al.

Acta pharmaceutica Sinica. B, 4(4), 258-265 (2014-08-01)

RNAs have diverse structures that include bulges and internal loops able to form tertiary contacts or serve as ligand binding sites. The recent increase in structural and functional information related to RNAs has put them in the limelight as a

Penicillins

xPharm: The Comprehensive Pharmacology Reference (2016)

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全球贸易项目编号

货号	GTIN
P4458-100ML	04061834374619
P4458-20ML	04061834374626

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