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Merck
CN

P4505

Sigma-Aldrich

Protamine sulfate

powder

别名:

硫酸鱼精蛋白

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关于此项目

CAS Number:
MDL编号:
UNSPSC代码:
12352202
NACRES:
NA.77
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Product Name

鱼精蛋白 硫酸盐 来源于鲱鱼, Grade III, histone, free(Millon test)

生物来源

fish (herring)

质量水平

类型

Grade III

表单

powder

杂质

histone, free (Millon test)

溶解性

6 M HCl: 25 mg/mL, clear, colorless to very faintly yellow

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应用

可用于从蛋白质样品中去除DNA,或用于纯化DNA结合蛋白。它可以用作逆转录病毒介导基因转移中的聚凝胺的替代物。

生化/生理作用

与由Esterquat-1组成的具有可比性的固体脂质纳米颗粒(SLN)相比,SLN形式的鱼精蛋白可更有效地促进质粒DNA的转染,而且细胞毒性更低。
硫酸鱼精蛋白是一种可与 DNA 结合并产生沉淀的小阳离子蛋白。它能中和肝素的抗凝血活性,还可抑制脂蛋白脂肪酶。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

动植物源性产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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L T Hansen et al.
International journal of food microbiology, 66(3), 149-161 (2001-06-29)
The antimicrobial effect of protamine (clupeine) on a range of gram-positive and gram-negative foodborne pathogens and spoilage bacteria, was evaluated using an agar dilution assay and a broth dilution assay with Alamar Blue as growth indicator. Protamine was tested alone
Chengming Liu et al.
BMC medicine, 20(1), 187-187 (2022-05-14)
Cytokines have been reported to alter the response to immune checkpoint inhibitors (ICIs) in patients with the tumor in accordance with their plasma concentrations. Here, we aimed to identify the key cytokines which influenced the responses and stimulated resistance to
L Willmitzer et al.
Biophysics of structure and mechanism, 6(2), 95-110 (1980-01-01)
The thermodynamics of protamine-DNA interation was investigated with clupeine Z from herring labeled at its amino terminus with fluorescein. The ionic strength dependence, the influence of protamine phosphorylation, of the native DNA conformation, using native and heat-denatured DNA, and of
Lisanne T Laagland et al.
JOR spine, 5(3), e1219-e1219 (2022-10-08)
Repopulating the degenerated intervertebral disc (IVD) with tissue-specific nucleus pulposus cells (NPCs) has already been shown to promote regeneration in various species. Yet the applicability of NPCs as cell-based therapy has been hampered by the low cell numbers that can
A Bonincontro et al.
Physics in medicine and biology, 34(5), 609-616 (1989-05-01)
The complex dielectric constant of arginine and protamine from herring sperm (clupeine) and their complexes with herring sperm DNA was measured at 10 GHz in the temperature range -20 to +45 degrees C by a microwave cavity perturbation method. The

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