一般描述
研究领域：细胞信号传导磷酸二酯酶i （PDEI）存在于三种亚型PDE1A、PDE1B和PDE1C(2)中，它们位于心血管、中枢神经系统和其他器官中。
应用
本文用西方响尾蛇（Crotalus atrox）的磷酸二酯酶I分析了磷酸二酯酶I对中性粒细胞内钙浓度的影响。其也可与其他酶联合用于测定磷酸酶的活性。
磷酸二酯酶I是西部菱形响尾蛇的产物P4506，用于钙调素的磷酸二酯酶活化试验。 它被加入水解AMP。
生化/生理作用
磷酸二酯酶I可破坏磷酸二酯键并催化各种核苷酸多磷酸盐的水解。 磷酸二酯酶I是由磷脂酰肌醇特异性磷脂酶C从真核生物细胞膜释放出来的。磷酸二酯酶I可以水解3′,5′-环腺苷单磷酸（cAMP）和3′,5′-环鸟苷单磷酸（cGMP）。它与Ca2+/钙调蛋白（CaM）形成复合物，导致其催化活性的激活。PDEI显示出治疗癌症、疾病、神经认知、肺、代谢、心脏、肾脏、神经系统疾病和内分泌异常的生物治疗效果。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
动植物源性产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
T Nakabayashi et al.
Journal of biochemistry, 99(3), 703-712 (1986-03-01)
From various rat organs, alkaline phosphodiesterase I was liberated by the action of phosphatidylinositol-specific phospholipase C obtained from Bacillus thuringiensis. Especially, a large amount of alkaline phosphodiesterase I was released from slices of small intestine, testis, lung, and kidney, but
Omer Murik et al.
The Plant journal : for cell and molecular biology, 101(6), 1269-1286 (2019-10-29)
Mitochondria serve as major sites of ATP production and play key roles in many other metabolic processes that are critical to the cell. As relicts of an ancient bacterial endosymbiont, mitochondria contain their own hereditary material (i.e. mtDNA, or mitogenome)
Assessment of bioavailable organic phosphorus in tropical forest soils by organic acid extraction and phosphatase hydrolysis
Darch T, et al.
Geoderma, 284, 93-102 (2016)
Phosphodiesterase I, a novel adhesion molecule and/or cytokine involved in oligodendrocyte function.
B Fuss et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 17(23), 9095-9103 (1997-12-31)
One of the more complex developmental processes occurring postnatally in the CNS is the formation of the myelin sheath by oligodendrocytes. To examine the molecular events that take place during myelination, we isolated oligodendrocyte-derived cDNA clones, one of which (p421.HB)
Identification of Lys49-PLA2 from crude venom of Crotalus atrox as a human neutrophil-calcium modulating protein
Sultan MD, et al.
The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology, 20(2), 177-183 (2016)
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