P4524
β-内酰胺酶 来源于阴沟肠杆菌
Type IV, lyophilized powder, 0.2-0.6 units/mg protein (using benzylpenicillin)
别名:
β-内酰胺酶 I, β-内酰胺酶 II, 头孢菌素, 青霉素 来源于阴沟肠杆菌, 青霉素酰氨基-β-内酰胺水解酶
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关于此项目
化学文摘社编号:
UNSPSC Code:
12352204
NACRES:
NA.54
MDL number:
Specific activity:
0.2-0.6 units/mg protein (using benzylpenicillin)
Biological source:
bacterial (Enterobacter cloacae)
biological source
bacterial (Enterobacter cloacae)
type
Type IV
form
lyophilized powder
specific activity
0.2-0.6 units/mg protein (using benzylpenicillin)
mol wt
29 kDa
composition
Protein, ~60%
technique(s)
enzyme immunoassay: suitable
suitability
suitable for enzyme test
application(s)
pharmaceutical
storage temp.
2-8°C
Quality Level
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General description
β-内酰胺酶是29 kDa的单体酶。该产品由阴沟肠杆菌生产，以冻干粉形式提供。它可充当β-内酰胺抗生素的靶蛋白。该酶存在于革兰氏阴性菌中。
Application
β-内酰胺酶可通过打开β-内酰胺环来使β-内酰胺抗生素失活。 β-内酰胺酶可用于研究抗生素耐药性和耐药性抑制。 产品P4524由阴沟肠杆菌生产，以冻干粉形式提供。
β-来自阴沟肠杆菌的内酰胺酶已被用于母婴定量血液培养，以避免任何残留现象。它还被用作胎盘培养用Mueller Hinton（MH）肉汤的成分。
Biochem/physiol Actions
β-内酰胺酶被用于通过打开 β-内酰胺环灭活β-内酰胺类抗生素。
Physical form
含有磷酸钠缓冲盐的冻干粉
Analysis Note
缩二脲法测定蛋白
Other Notes
一个单元将在25°C，ph7.0 时每分钟水解 1.0μmol苄青霉素。此国际单位（以苄青霉素为底物）约等于 600levy 或 75pollock 单位。
signalword
Danger
hcodes
Hazard Classifications
Resp. Sens. 1 - Skin Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
常规特殊物品
此项目有
Protein-protein interactions monitored in mammalian cells via complementation of beta-lactamase enzyme fragments
Wehrman T, et al.
Proceedings of the National Academy of Sciences of the USA, 99(6), 3469-3474 (2002)
Persistent bacteremia in rabbit fetuses despite maternal antibiotic therapy in a novel intrauterine-infection model
Gras-Le Guen C, et al.
Antimicrobial Agents and Chemotherapy, 47(7), 2125-2130 (2003)
Past and present perspectives on beta$-lactamases
Bush K
Antimicrobial Agents and Chemotherapy, 62(10) (2018)
P J Johnsen et al.
Genetics, 181(4), 1521-1533 (2009-02-05)
We present a new hypothesis for the selective pressures responsible for maintaining natural competence and transformation. Our hypothesis is based in part on the observation that in Bacillus subtilis, where transformation is widespread, competence is associated with periods of nongrowth
Jung-Ho Shin et al.
EMBO reports, 22(2), e51790-e51790 (2021-01-20)
Bactericidal antibiotics are powerful agents due to their ability to convert essential bacterial functions into lethal processes. However, many important bacterial pathogens are remarkably tolerant against bactericidal antibiotics due to inducible damage repair responses. The cell wall damage response two-component
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