P4620
PD 146176
≥98% (HPLC), solid
别名:
6,11-二氢 [1] 苯并硫代吡喃 [4,3-b] 吲哚
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关于此项目
经验公式（希尔记法）:
C15H11NS
化学文摘社编号:
分子量:
237.32
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
MDL number:
产品名称
PD 146176, ≥98% (HPLC), solid
InChI key
ZGOOPZVQMLHPFM-UHFFFAOYSA-N
SMILES string
C1Sc2ccccc2-c3[nH]c4ccccc4c13
InChI
1S/C15H11NS/c1-3-7-13-10(5-1)12-9-17-14-8-4-2-6-11(14)15(12)16-13/h1-8,16H,9H2
assay
≥98% (HPLC)
form
solid
color
white to beige
solubility
DMSO: soluble >10 mg/mL
H2O: insoluble
Quality Level
Gene Information
human ... ALOX15(246)
mouse ... ALOX15(11687)
rat ... ALOX15(81639)
相关类别
Application
PD 146176已被用于研究其对脂肪组织中离体白细胞三烯B4（LTB4）和脂氧素A4（LXA4）分泌的影响。
Biochem/physiol Actions
15-脂氧合酶抑制剂
PD 146176通过抑制5-脂氧合酶1（15-LOX-1）来阻断神经保护素D1（NPD1）和类花生酸的合成。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
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