Application
蛋白 G 已用于使用表面等离子体共振 (SPR) 分析 mAb（单克隆抗体）与 hCG（人绒毛膜促性腺激素）的协同作用，以及用于从 RA（类风湿关节炎）患者和 MRL- lpr 小鼠中获得的血清 IgG 半乳糖基化。
Biochem/physiol Actions
蛋白 G 通过其蛋白结合特性参与链球菌逃避宿主防御反应。它与 α2-微球蛋白相互作用，α2-微球蛋白是人血浆的主要抑制剂。
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General description
基因工程截短蛋白 G；保留与 IgG 的亲和力，但缺乏白蛋白和 Fab 结合位点以及膜结合区域。
蛋白 G 是 G 群 链球菌 蛋白，是一个大的多结构域细胞壁蛋白。通过其重复的 55 个氨基酸结构域与 IgG（免疫球蛋白）的 Fc 区相互作用。菌株 GX7809 和 GX7805 分别含有两个和三个这样的蛋白重复序列。
Physical form
从水中冻干。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
此项目有
C R Goward et al.
The Biochemical journal, 267(1), 171-177 (1990-04-01)
The gene for Protein G from Streptococcus strain G148 was cloned and expressed in Escherichia coli. The regions on the gene corresponding to the albumin-binding domains and the Fab-binding region were then deleted by site-directed mutagenesis. The translation of regions
Arie Ryvkin et al.
PloS one, 7(8), e41469-e41469 (2012-08-08)
Polyclonal serum consists of vast collections of antibodies, products of differentiated B-cells. The spectrum of antibody specificities is dynamic and varies with age, physiology, and exposure to pathological insults. The complete repertoire of antibody specificities in blood, the IgOme, is
Purification and some properties of streptococcal protein G, a novel IgG-binding reagent.
Bjorck L and Kronvall G
Journal of Immunology, 133(2), 969-974 (1984)
P A Jeddi et al.
Immunology, 87(4), 654-659 (1996-04-01)
Reduced galactosylation of immunoglobulin G (IgG) is well documented in rheumatoid arthritis (RA), but the reason for this defect is still unknown. There is some evidence supporting a defect in the biosynthetic pathway, and a reduction in the level of
Oleksiy Krupin et al.
Sensors (Basel, Switzerland), 19(3) (2019-02-06)
Straight long-range surface plasmon-polariton (LRSPP) waveguides as biosensors for label-free detection are discussed. The sensors consist of 5-μm-wide 35-nm-thick gold stripes embedded in a low-index optical-grade fluoropolymer (CYTOPTM) with fluidic channels etched to the Au surface of the stripes. This
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