一般描述
基因工程截短蛋白 G;保留与 IgG 的亲和力,但缺乏白蛋白和 Fab 结合位点以及膜结合区域。
蛋白 G 是 G 群 链球菌 蛋白,是一个大的多结构域细胞壁蛋白。通过其重复的 55 个氨基酸结构域与 IgG(免疫球蛋白)的 Fc 区相互作用。菌株 GX7809 和 GX7805 分别含有两个和三个这样的蛋白重复序列。
应用
蛋白 G 已用于使用表面等离子体共振 (SPR) 分析 mAb(单克隆抗体)与 hCG(人绒毛膜促性腺激素)的协同作用,以及用于从 RA(类风湿关节炎)患者和 MRL- lpr 小鼠中获得的血清 IgG 半乳糖基化。
生化/生理作用
蛋白 G 通过其蛋白结合特性参与链球菌逃避宿主防御反应。它与 α2-微球蛋白相互作用,α2-微球蛋白是人血浆的主要抑制剂。
外形
从水中冻干。
免责声明
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储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
此项目有
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