P4888
4α-佛波醇
powder
别名:
4α,9α,12β,13α,20-pentahydroxytiglia-1,6-dien-3-one, 4α-PHR, Isophorbol
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关于此项目
经验公式（希尔记法）:
C20H28O6
化学文摘社编号:
分子量:
364.43
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
form
powder
color
white
storage temp.
−20°C
SMILES string
C[C@@H]1[C@@H](O)[C@]2(O)[C@H]([C@@H]3C=C(CO)C[C@]4(O)[C@@H](C=C(C)C4=O)[C@@]13O)C2(C)C
InChI
1S/C20H28O6/c1-9-5-13-18(24,15(9)22)7-11(8-21)6-12-14-17(3,4)20(14,26)16(23)10(2)19(12,13)25/h5-6,10,12-14,16,21,23-26H,7-8H2,1-4H3/t10-,12+,13-,14-,16-,18+,19-,20-/m1/s1
InChI key
QGVLYPPODPLXMB-FYYCTCHMSA-N
Application
Phorbol that is not biologically active; can be used as a negative control
signalword
Danger
Hazard Classifications
Acute Tox. 2 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
新产品
此项目有
Emad Afrasiabi et al.
Molecular and cellular endocrinology, 292(1-2), 26-35 (2008-06-11)
Phorbol 12-myristate 13-acetate (PMA) is known to affect a variety of cellular processes, including cell proliferation, differentiation, and migration. PMA has been shown to promote antiproliferative and antimigratory effects in many types of cancer cells. Our findings show that PMA
Vijay Lyall et al.
Journal of neurophysiology, 102(3), 1591-1605 (2009-06-26)
The regulation of the benzamil (Bz)-insensitive salt taste receptor was investigated by intracellular Ca2+ ([Ca2+]i), protein kinase C (PKC), and the Ca2+-dependent serine-threonine phosphatase, calcineurin (PP2B), by monitoring chorda tympani taste nerve responses to 0.1 M NaCl solutions containing Bz
Tetsuro Kondo et al.
The European journal of neuroscience, 22(7), 1817-1820 (2005-10-04)
The phosphorylation of ionotropic glutamate receptors (iGluRs) by protein kinases plays a crucial role in synaptic plasticity. In the cerebellum, protein kinase C (PKC) activation is required for the induction of long-term depression (LTD) at parallel fibre-Purkinje cell synapses. Although
Undurti N Das et al.
Prostaglandins, leukotrienes, and essential fatty acids, 74(3), 165-173 (2006-02-21)
The effect of gamma-linolenic acid (GLA) and prostaglandin E1 (PGE1) on gamma-radiation, diphenylhydantoin (DPH), benzo(a)pyrene (BP), and 4-alpha-phorbol-induced genetic damage to the bone marrow cells of mice, using the sensitive micronucleus (MN) test was investigated. PGE1 and its precursor GLA
R W Moore et al.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 134(3), 291-302 (2003-03-20)
In attempts to identify antibodies for Bursal Anti-Steroidogenic Peptide (BASP), rabbit serum was observed to reduce phorbol ester-stimulated chicken B-lymphocyte proliferation comparable to BASP. These experiments investigated the effects of IgG on B-lymphocyte proliferation. In Experiment 1, 3% rabbit serum
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