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Merck
CN

P4932

多粘菌素 B 硫酸盐

powder, non-animal origin, suitable for cell culture, BioReagent

别名:

Polymixin, Polymixin B, Polymixin B sulfate

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关于此项目

经验公式（希尔记法）:
C55H96N16O13 · 2H2SO4
化学文摘社编号:
1405-20-5
分子量:
1385.61
NACRES:
NA.76
UNSPSC Code:
12352207
EC Number:
215-774-7
MDL number:
MFCD00131991

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产品名称

多粘菌素 B 硫酸盐, powder, BioReagent, suitable for cell culture

InChI key

HNDFYNOVSOOGDU-UHFFFAOYSA-N

InChI

1S/C48H82N16O13.H2O4S/c1-27(2)24-37-47(76)59-32(11-19-52)41(70)56-31(10-18-51)43(72)61-35(14-22-65)39(68)54-21-13-34(45(74)57-33(12-20-53)44(73)64-38(48(77)63-37)25-28-6-4-3-5-7-28)60-42(71)30(9-17-50)58-46(75)36(15-23-66)62-40(69)29(8-16-49)55-26-67;1-5(2,3)4/h3-7,26-27,29-38,65-66H,8-25,49-53H2,1-2H3,(H,54,68)(H,55,67)(H,56,70)(H,57,74)(H,58,75)(H,59,76)(H,60,71)(H,61,72)(H,62,69)(H,63,77)(H,64,73);(H2,1,2,3,4)

SMILES string

O=C(C(NC(C(CCN)NC(CCCCC(C)CC)=O)=O)C(C)O)NC(CCN)C(NC(CCNC(C(NC(C(NC(C(CCN)N1)=O)CCN)=O)C(O)C)=O)C(NC(CCN)C(NC(CC2=CC=CC=C2)C(NC(CC(C)C)C1=O)=O)=O)=O)=O.O=S(O)(O)=O

product line

BioReagent

form

powder

potency

≥6,000 USP units per mg

technique(s)

cell culture | mammalian: suitable

antibiotic activity spectrum

Gram-negative bacteria

mode of action

cell membrane | interferes

storage temp.

2-8°C

Quality Level

200

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相关类别

Biochem/physiol Actions

作用机制：多粘菌素B硫酸盐结合到细菌脂多糖的脂质部分†上，通过诱导足够大的孔来破坏细胞质膜，使核苷酸泄漏到细菌的细胞壁中。 这可破环细胞质膜的半透性。

抗菌谱：对大多数革兰氏阴性杆菌，包括 大肠杆菌 ，真菌和革兰氏阳性菌都有杀菌作用。
Polymyxin B sulfate has been used clinically to treat infections of the urinary tract, meninges and blood stream caused by susceptible strains of Pseudomonas aeruginosa. It also has been used in studying multidrug-resistant pathogens, as an immobilized agent for removal of endotoxins, and to induce pore formation in the membranes of cortex cells from excised sorghum roots.

Application

Polymyxin B sulfate salt has been used:
  • for the treatment of BAC-1.2F5 murine macrophages as an LPS (lipopolysaccharide) inhibitor
  • as positive and negative control during microbicidal concentration (MCC) assay

Disclaimer

As supplied, the product should be stored at 2-8°C in the dark. No change was observed in retained samples after three years′ of storage in these conditions. Stock solutions should be sterile filtered and stored at 2-8°C. They are stable at 37°C for 5 days.

General description

Polymyxin B is a member of the polymyxin group of antibiotics, obtained from different strains of Bacillus polymyxa and related species. It contains a cyclic heptapeptide unit and a tripeptide side chain, which is N-acylated by a fatty acyl residue. Polymyxin B sulfate salt is generally used for the treatment of Gram-negative bacterial infections.
Chemical structure: peptide

Other Notes

1mu,5mu
Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.

Preparation Note

Polymyxin B sulfate is soluble in water at 50 mg/mL, producing a very slightly hazy, colorless to yellow solution. It has only minimal solubility in any organic solvent. For example, it has a solubility of 0.115 mg/mL in ethanol.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

法规信息

涉药品监管产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000485050
0000485050
0000465846
0000465846
0000421309

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P Dello Sbarba et al.
Cytokine, 8(6), 488-494 (1996-06-01)
Macrophage colony-stimulating factor (M-CSF) is the main growth factor for mononuclear phagocytes. Responsiveness to growth factors is reduced in the course of functional activation of macrophages. We studied the interference of the macrophage activator interleukin 2 (IL-2) with the response
Franz G Zingl et al.
Cell host & microbe, 27(2), 225-237 (2020-01-07)
Gram-negative bacteria release outer membrane vesicles into the external milieu to deliver effector molecules that alter the host and facilitate virulence. Vesicle formation is driven by phospholipid accumulation in the outer membrane and regulated by the phospholipid transporter VacJ/Yrb. We use
J W Kang et al.
Journal of chromatography. A, 879(2), 211-218 (2000-07-13)
A capillary zone electrophoresis method for analysis of polymyxin B sulfate is described. In this method, triethanolamine (TEA)-phosphate buffer at pH 2.5 was employed to reduce the adsorption of analyte onto the capillary wall. Methyl-beta-cyclodextrin (M-beta-CD) and 2-propanol (IPA) were
M C Skinner et al.
Antimicrobial agents and chemotherapy, 53(4), 1482-1489 (2009-02-04)
A topical microbicide that women can use to prevent sexually transmitted diseases (STDs) is essential, and many microbicide candidates are being tested for activity against human immunodeficiency virus and other STDs, including Chlamydia trachomatis. Screening assays for assessing the activity
Sineenart Sengyee et al.
PLoS neglected tropical diseases, 12(2), e0006287-e0006287 (2018-02-24)
Burkholderia pseudomallei is an environmental bacterium that causes melioidosis, a major community-acquired infection in tropical regions. Melioidosis presents with a range of clinical symptoms, is often characterized by a robust inflammatory response, may relapse after treatment, and results in high
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