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P5052

5α-Pregnan-3α-ol-11,20-dione

Name: 5α-Pregnan-3α-ol-11,20-dione
Brand: SIGMA

powder, ≥98% (TLC)

别名:

3-Hydroxy-5α-pregnane-11,20-dione, Alfaxalone

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关于此项目

化学文摘社编号:

23930-19-0

NACRES:

NA.77

PubChem Substance ID:

24278637

UNSPSC Code:

12352200

MDL number:

MFCD00083468

Assay:

≥98% (TLC)

Form:

powder

Quality level:

200

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属性

Quality Level

200

assay

≥98% (TLC)

form

powder

drug control

USDEA Schedule IV

color

white

solubility

chloroform: ≥5 mg/mL, clear, colorless

SMILES string

[H][C@@]12CC[C@@]3([H])[C@]4([H])CC[C@H](C(C)=O)[C@@]4(C)CC(=O)[C@]3([H])[C@@]1(C)CC[C@@H](O)C2

InChI

1S/C21H32O3/c1-12(22)16-6-7-17-15-5-4-13-10-14(23)8-9-20(13,2)19(15)18(24)11-21(16,17)3/h13-17,19,23H,4-11H2,1-3H3/t13-,14+,15-,16+,17-,19+,20-,21+/m0/s1

InChI key

DUHUCHOQIDJXAT-OLVMNOGESA-N

Gene Information

human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562), GABRG2(2566)

说明

Biochem/physiol Actions

Neurosteroid; positive allosteric modulator of the GABA_A receptor; anesthetic.

Synthetic steroid compound alphaxalone (AFX) - 5α-Pregnan-3α-ol-11,20-dione- is a neurosteroid that directly activates and potentiates GABA_A receptor-activated membrane current (IGABA). It acts as a positive allosteric modulator of the GABA_A receptor; anesthetic. The alpha subunit subtype of GABA_A determines the efficacy, but not the potency, of AFX neuroactive steroid to potentiate IGABA.

pictograms

GHS06

signalword

Danger

hcodes

H301

pcodes

P301 + P310

Hazard Classifications

Acute Tox. 3 Oral

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

法规信息

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Increased membrane cholesterol reduces the potentiation of GABA(A) currents by neurosteroids in dissociated hippocampal neurones.

T Sooksawate et al.

Neuropharmacology, 37(9), 1103-1110 (1998-12-02)

The effects of increased membrane cholesterol on the potentiation of GABA(A) currents by pregnanolone (5beta-pregnan-3alpha-ol-20-one), allopregnanolone (5alpha-pregnan-3alpha-ol-20-one), alphaxalone (5alpha-pregnan-3alpha-ol-11,20-dione) and propofol were investigated in acutely dissociated rat hippocampal neurones using the whole-cell patch clamp technique. Cholesterol enrichment of the neurones

Subunit dependent modulation of GABAA receptor function by neuroactive steroids.

R Maitra et al.

Brain research, 819(1-2), 75-82 (1999-03-20)

Neurosteroids are potent, endogenous modulators of GABAA receptor function in the central nervous system. The endogenous progesterone metabolite allopregnanolone (ALP) and the synthetic steroid compound alphaxalone (AFX) have been shown to both directly activate and potentiate GABAA receptor-activated membrane current

全球贸易项目编号

货号	GTIN
P5052-10MG	04061832092706