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P5057

Paromomycin sulfate salt 硫酸盐

Name: Paromomycin sulfate salt 硫酸盐
Brand: SIGMA

powder, suitable for cell culture, BioReagent

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经验公式（希尔记法）:

C₂₃H₄₅N₅O₁₄ · xH₂SO₄

化学文摘社编号:

1263-89-4

分子量:

615.63 (free base basis)

UNSPSC Code:

12352207

PubChem Substance ID:

24898585

NACRES:

NA.76

Beilstein/REAXYS Number:

5715182

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产品名称

Paromomycin sulfate salt 硫酸盐, powder, BioReagent, suitable for cell culture, potency: ≥675 μg per mg

product line

BioReagent

Quality Level

200

form

powder

potency

≥675 μg per mg

technique(s)

cell culture | mammalian: suitable

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

mode of action

protein synthesis | interferes

SMILES string

O[C@H]1[C@H](O)[C@@H](CO)O[C@H](O[C@@]2([H])[C@H](O[C@@]3([H])[C@H](O)[C@H](O[C@]4([H])[C@H](N)[C@@H](O)[C@H](O)[C@H](CN)O4)[C@@H](CO)O3)[C@@H](O)[C@H](N)C[C@@H]2N)[C@@H]1N.C

InChI

1S/C23H45N5O14.CH4/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22;/h5-23,29-36H,1-4,24-28H2;1H4/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+;/m1./s1

InChI key

OYJABWUHUYVDMJ-UDXJMMFXSA-N

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General description

Paromomycin or aminosidine, an aminoglycoside belongs to the class of aminoglycosides. This nonabsorbable antibiotic is found at high level in the lumen of the colon.

Chemical structure: aminoglycoside

Application

Paromomycin sulfate salt has been used as a positive control to compare the purine analog antiviral 2′,3′-dideoxyinosine (ddI).

Paromomycin sulfate salt has been used as a:
reference compound in antileishmanial activity
RNA-binding ligand and interacts with aptamer. This interaction prevents the binding (and cutting) of dicer to RNA duplex.

Recommended for use in cell culture applications at 100mg/L.

Biochem/physiol Actions

Paromomycin possesses antileishmanial and antibacterial activities. It is used to cure visceral leishmaniasis (VL) and cutaneous leishmaniasis (CL). This aminocyclitol glycoside is active against gram-negative and gram-positive bacteria. It is also active against E. histolytica, D. fragilis and several cestodes, like Taenia saginata, Taenia solium etc.

Antimicrobial spectrum: Gram-negative and Gram-positive bacteria, some protozoan species, and limited antihelminth.
Mode of Action: Inhibits initiation and elongation during protein synthesis.

Paromomycin inhibits the initiation and elongation steps of protein synthesis by binding to 16S ribosomal RNA. Paramomycin binds to the A site, which causes defective polypeptide chains to be produced and leads to cell death.

Other Notes

1g,5g

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

新产品

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000474741

0000424097

0000424094

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Use of a non-adherent cell culture system for testing the effect of 2,3'-dideoxyinosine against Cryptosporidium parvum

Lawton P, et al.

FEMS Microbiology Letters, 176(1), 235-240 (1999)

Leishmaniasis

Manson's Tropical Infectious Diseases (2014)

Antiparasitic Agents

Infectious Diseases, 2, 1345-1372 (2017)

Nanoarchitectures for Neglected Tropical Protozoal Diseases: Challenges and State of the Art

Nano- and Microscale Drug Delivery Systems, 439-480 (2017)

Paromomycin

Davidson RN, et al.

Transactions of the Royal Society of Tropical Medicine and Hygiene, 103(7), 653-660 (2009)

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全球贸易项目编号

货号	GTIN
P5057-5G	04061834375654
P5057-1G	04061834375647

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