P5084
PTIO
NO activity inhibitor, powder
别名:
2-苯基-4,4,5,5-四甲基咪唑啉-1-氧代 3-氧化物
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关于此项目
经验公式（希尔记法）:
C13H17N2O2
化学文摘社编号:
分子量:
233.29
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.32
MDL number:
产品名称
PTIO,
SMILES string
CC1(C)N([O])C(c2ccccc2)=[N+]([O-])C1(C)C
InChI
1S/C13H17N2O2/c1-12(2)13(3,4)15(17)11(14(12)16)10-8-6-5-7-9-10/h5-9H,1-4H3
InChI key
DYUUGILMVYJEHY-UHFFFAOYSA-N
form
powder
storage temp.
2-8°C
Quality Level
Application
2-苯基-4，4，5，5，-四甲基咪唑啉-1-氧代 3-氧化物 (PTIO) 已被用作一氧化氮 (NO) 清除剂。
Biochem/physiol Actions
2-苯基-4, 4, 5, 5-四甲基咪唑-1-氧代 3-氧化物 (PTIOs) 衍生物与一氧化氮 (NO) 反应生成相应的的亚氨基氮氧化物 (PTIs) 和二氧化氮 (NO2)。
一种稳定的一氧化氮自由基清除剂；不影响 NO 合成酶而影响 NO；对无生物活性有显著抑制活性。
稳定的一氧化氮自由基清除剂，不影响 NO 合成酶；抑制 NO 活性。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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International journal of radiation biology, 88(10), 751-762 (2012-06-20)
To investigate the mechanisms regulating the pathways of the bystander transmission in vitro, focusing on the radiation-perturbed signalling (via Interleukine 6, IL-6) of the irradiated cells after exposure to low doses of different radiation types. An integrated 'systems radiation biology'
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Activated monocytes/macrophages are known to release toxic materials. Identification of these materials is important for developing more effective treatments for inflammatory disorders where self attack occurs. We stimulated human monocytes and THP-1 cells with LPS/IFNγ and measured the toxic effects
Victoria P A Johnstone et al.
Learning & memory (Cold Spring Harbor, N.Y.), 18(10), 625-633 (2011-09-22)
Long-term potentiation (LTP) is an important process underlying learning and memory in the brain. At CA3-CA1 synapses in the hippocampus, three discrete forms of LTP (LTP1, 2, and 3) can be differentiated on the basis of maintenance and induction mechanisms.
Mona Soliman et al.
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Nitric oxide (NO) at optimal levels is considered beneficial to plant functioning. The present study was carried out to investigate the role of exogenously applied NO (100 and 150 µM sodium nitropurusside, SNP) in amelioration of nickel (Ni)-mediated oxidative effects
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