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Merck
CN

P5280

丙酮酸钠

powder, BioReagent, suitable for cell culture, suitable for insect cell culture, ≥99%

别名:

α酮基丙酸 钠盐, 2-氧代丙酸 钠盐, 丙酮酸 钠盐

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关于此项目

线性分子式:
CH3COCOONa
化学文摘社编号:
113-24-6
分子量:
110.04
UNSPSC Code:
12352207
NACRES:
NA.71
PubChem Substance ID:
24898615
EC Number:
204-024-4
Beilstein/REAXYS Number:
3568341
MDL number:
MFCD00002586

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产品名称

丙酮酸钠, powder, BioReagent, suitable for cell culture, suitable for insect cell culture, ≥99%

InChI key

DAEPDZWVDSPTHF-UHFFFAOYSA-M

InChI

1S/C3H4O3.Na/c1-2(4)3(5)6;/h1H3,(H,5,6);/q;+1/p-1

SMILES string

[Na+].CC(=O)C([O-])=O

product line

BioReagent

assay

≥99%

form

powder

technique(s)

cell culture | insect: suitable
cell culture | mammalian: suitable

mp

>300 °C (lit.)

solubility

H2O: 100 mg/mL

density

1.78 at 20 °C

application(s)

metabolomics

storage temp.

2-8°C

Quality Level

200

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Application

丙酮酸钠可用于：
  • 培养 MCF7ρ0（人乳腺癌细胞系）细胞作为母细胞
  • 作为细胞外流量(XF)检测培养基添加剂，培养细胞用于测定耗氧率(OCR)
  • 作为Eagle最低必需培养基添加剂，培养乳腺癌细胞(MCF-7)
  • 作为杜氏改良Eagle培养基(DMEM)类培养基和改良Eagle培养基(MEM)-α，用于睾丸细胞培养，评估培养基组分体外维持SSC的作用

Biochem/physiol Actions

丙酮酸钠具有抗氧化性能和抗氧自由基的保护作用。丙酮酸是糖酵解的一部分，也是许多代谢途径的中间产物。它可被转化为乙酰辅酶A并进入TCA循环。
丙酮酸钠可用作培养基和肉汤组分。外源给药后，对缺血再灌注损伤、出血性休克和败血性休克的各种动物模型具有保护作用。

Features and Benefits

  • 经过细胞培养和昆虫细胞培养验证

  • 用途广泛，适用于多种实验室和研究应用
  • 用于细胞生物学和生物化学研究的BioReagent级琥珀酸钠
  • 针对哺乳动物和昆虫细胞培养应用进行测试

General description

丙酮酸钠，来源丙酮酸，在细胞生物学、细胞培养和生物化学研究中应用广泛。 在糖酵解中葡萄糖被转化为丙酮同时大量产生ATP(三磷酸腺苷)。作为糖酵解途径的最终产物，丙酮酸是各种代谢途径（包括糖代谢）的中间体。在糖酵解中细胞自然地合成丙酮酸钠作为中间代谢产物，它不一定是所有细胞培养过程的必需补充剂。 但是，如果细胞是在添加丙酮酸钠的培养基中培养，继续使用丙酮酸钠时一种明智的做法，因为没有它细胞生长可能减缓。丙酮酸钠常被加入细胞培养基配方中，以增强肉汤和培养基的营养，通过提供容易获取的碳水化合物能量来源和葡萄糖来提高细胞生存率。它常被添加至生长培养基中，特别是用于快速增殖的细胞，如肿瘤细胞。此外，它参与氨基酸代谢并启动Kreb循环。细胞容易以丙酮酸钠作为碳源，进行能量生产和关键代谢途径，消除了对葡萄糖或氨基酸的生物合成的需求。由于无法将葡萄糖或氨基酸转化为丙酮酸，某些细胞系需要在培养基中补充丙酮酸。此外，丙酮酸钠可作为自由基清除剂，有效清除氧自由基（ROS），并有助于细胞健康和活力。

Other Notes

如需了解生化试剂系列的更多信息，请填写此表。

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H317,H319

Hazard Classifications

Eye Irrit. 2 - Skin Sens. 1B

存储类别

13 - Non Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000517907
0000517908
0000517908
0000517907
0000517933

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Rekin's Janky et al.
PLoS computational biology, 10(7), e1003731-e1003731 (2014-07-25)
Identifying master regulators of biological processes and mapping their downstream gene networks are key challenges in systems biology. We developed a computational method, called iRegulon, to reverse-engineer the transcriptional regulatory network underlying a co-expressed gene set using cis-regulatory sequence analysis.
Wei Yang et al.
Nature communications, 5, 3818-3818 (2014-05-03)
Polycomb Repressive Complex 1 and histone H2A ubiquitination (ubH2A) contribute to embryonic stem cell (ESC) pluripotency by repressing lineage-specific gene expression. However, whether active deubiquitination co-regulates ubH2A levels in ESCs and during differentiation is not known. Here we report that
Lotta Tengroth et al.
PloS one, 9(6), e98239-e98239 (2014-06-03)
The human nasal epithelium is an important physical barrier, and a part of the innate immune defense that protect against pathogens. The epithelial cells recognize microbial components by pattern-recognition receptors (PRRs), and thereby trigger an immune response. Even though TLR3
Philipp Müller et al.
Cancer immunology research, 2(8), 741-755 (2014-06-12)
Antibody-drug conjugates (ADC) are emerging as powerful treatment strategies with outstanding target-specificity and high therapeutic activity in patients with cancer. Brentuximab vedotin represents a first-in-class ADC directed against CD30(+) malignancies. We hypothesized that its sustained clinical responses could be related
Athanasia E Christakou et al.
Lab on a chip, 15(15), 3222-3231 (2015-07-02)
We demonstrate a simple method for three-dimensional (3D) cell culture controlled by ultrasonic standing waves in a multi-well microplate. The method gently arranges cells in a suspension into a single aggregate in each well of the microplate and, by this
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需氧糖酵解和瓦博格效应

本页面介绍了一篇有关瓦博格效应的文章，以及其如何能够在正常氧气水平下，增强肿瘤细胞中葡萄糖向乳酸的转化。Otto Heinrich Warburg在1924年证明，癌细胞显示出对糖酵解的依赖性增加，以满足他们的能量需求，无论是否有充足的氧气存在。

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Product Information Sheet - P5280

Product Information Sheet

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

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