Merck
CN

P5280

Sigma-Aldrich

丙酮酸钠

powder, BioReagent, suitable for cell culture, suitable for insect cell culture, ≥99%

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别名:
α酮基丙酸 钠盐, 2-氧代丙酸 钠盐, 丙酮酸 钠盐
线性分子式:
CH3COCOONa
CAS号:
分子量:
110.04
Beilstein:
3568341
EC 号:
MDL编号:
PubChem化学物质编号:
NACRES:
NA.71

产品线

BioReagent

检测方案

≥99%

形式

powder

technique(s)

cell culture | insect: suitable
cell culture | mammalian: suitable

mp

>300 °C (lit.)

溶解性

H2O: 100 mg/mL

储存温度

2-8°C

SMILES string

[Na+].CC(=O)C([O-])=O

InChI

1S/C3H4O3.Na/c1-2(4)3(5)6;/h1H3,(H,5,6);/q;+1/p-1

InChI key

DAEPDZWVDSPTHF-UHFFFAOYSA-M

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此商品
P4562P8574P2256
Sodium pyruvate powder, BioReagent, suitable for cell culture, suitable for insect cell culture, ≥99%

Sigma-Aldrich

P5280

丙酮酸钠

Essential+ Grade
Sodium pyruvate powder, BioXtra, suitable for mouse embryo cell culture

Sigma-Aldrich

P4562

丙酮酸钠

-
Sodium pyruvate BioXtra, ≥99%

Sigma-Aldrich

P8574

丙酮酸钠

Premium Grade
Sodium pyruvate ReagentPlus®, ≥99%

Sigma-Aldrich

P2256

丙酮酸钠

-
form

powder

form

powder

form

powder

form

powder

mp

>300 °C (lit.)

mp

>300 °C (lit.)

mp

>300 °C (lit.)

mp

>300 °C (lit.)

solubility

H2O: 100 mg/mL

solubility

H2O: 100 mg/mL

solubility

H2O: 1 M, clear, colorless

solubility

H2O: 100 mg/mL, clear, colorless to faintly yellow

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

Quality Level

200

Quality Level

-

Quality Level

200

Quality Level

200

一般描述

Sodium pyruvate, derived from pyruvic acid, finds extensive use in cell biology, cell culture, and biochemical research. As the end-product of the glycolysis pathway, where glucose is converted into pyruvate with the energetic production of ATP (Adenosine Triphosphate), pyruvate serves as an intermediary in numerous metabolic pathways, including sugar metabolism. While cells naturally synthesize sodium pyruvate as an intermediate metabolite in glycolysis, it isn′t universally necessary as a supplement for all cell cultures. However, if cells have been cultivated in a medium enriched with sodium pyruvate, it′s advisable to continue its use as cell growth may diminish without it.Sodium pyruvate is frequently incorporated into cell culture formulations to fortify broths and media, enhancing cell survival by providing an easily-accessible carbohydrate energy source alongside glucose. It′s often added to the growth medium, particularly for rapidly proliferating cells like tumor cells. Furthermore, it participates in amino acid metabolism and initiates the Krebs cycle. Cells can readily utilize sodium pyruvate as a carbon source for energy production and crucial metabolic pathways, eliminating the need for biosynthetic production from glucose or amino acids.Certain cell lines require supplemental pyruvate in the culture media due to their inability to convert glucose or amino acids into pyruvate. Additionally, sodium pyruvate serves as a free radical scavenger, effectively quenching reactive oxygen species (ROS) and contributing to cellular health and viability.

应用

丙酮酸钠可用于:
  • 培养 MCF7ρ0(人乳腺癌细胞系)细胞作为母细胞
  • 作为细胞外流量(XF)检测培养基添加剂,培养细胞用于测定耗氧率(OCR)
  • 作为Eagle最低必需培养基添加剂,培养乳腺癌细胞(MCF-7)
  • 作为杜氏改良Eagle培养基(DMEM)类培养基和改良Eagle培养基(MEM)-α,用于睾丸细胞培养,评估培养基组分体外维持SSC的作用

生化/生理作用

丙酮酸钠具有抗氧化性能和抗氧自由基的保护作用。丙酮酸是糖酵解的一部分,也是许多代谢途径的中间产物。它可被转化为乙酰辅酶A并进入TCA循环。
丙酮酸钠可用作培养基和肉汤组分。外源给药后,对缺血再灌注损伤、出血性休克和败血性休克的各种动物模型具有保护作用。

特点和优势

  • 经过细胞培养和昆虫细胞培养验证

  • Versatile and adaptable for a wide variety of laboratory and research applications
  • BioReagent Grade Sodium succinate for your Cell Biology and Biochemical research
  • Tested for Mammalian and Insect cell culture applications

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警示用语:

Warning

危险声明

危险分类

Eye Irrit. 2 - Skin Sens. 1B

储存分类代码

13 - Non Combustible Solids

WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


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Identifying master regulators of biological processes and mapping their downstream gene networks are key challenges in systems biology. We developed a computational method, called iRegulon, to reverse-engineer the transcriptional regulatory network underlying a co-expressed gene set using cis-regulatory sequence analysis.
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Polycomb Repressive Complex 1 and histone H2A ubiquitination (ubH2A) contribute to embryonic stem cell (ESC) pluripotency by repressing lineage-specific gene expression. However, whether active deubiquitination co-regulates ubH2A levels in ESCs and during differentiation is not known. Here we report that
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