P5390
前列腺素 B2
≥98%, synthetic
别名:
(5Z,13E,15S)-15-Hydroxy-9-oxoprosta-5,8(12),13-trien-1-oic acid, PGB2
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关于此项目
经验公式（希尔记法）:
C20H30O4
化学文摘社编号:
分子量:
334.45
UNSPSC Code:
12352211
NACRES:
NA.77
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
2153006
产品名称
前列腺素 B2, ≥98%, synthetic
biological source
synthetic
assay
≥98%
form
solution
solubility
ethanol: ~100 mg/mL
PBS, pH 7.2: ~2 mg/mL
DMSO: ~50 mg/mL
InChI
1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1
SMILES string
CCCCC[C@H](O)\C=C\C1=C(C\C=C/CCCC(O)=O)C(=O)CC1
InChI key
PRFXRIUZNKLRHM-HKVRTXJWSA-N
storage temp.
−20°C
Quality Level
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Application
Prostaglandin B2 has been used as an internal standard in high-performance liquid chromatography (HPLC).
Biochem/physiol Actions
Prostaglandin B2 (PGB2) is an eicosanoid and a lipid mediator. It is synthesized by the dehydration of PGE2. It is a primary prostaglandin associated with the osteoblasts and may induce pulmonary hypertension. PGB2 is also reported to inhibit glucagon stimulated glycogenolysis and forskolin-stimulated adenylate cyclase activity in plasma membranes.
Physical form
Prostaglandin B2 is supplied as a solution in methyl acetate
Preparation Note
PGB2 is provided as a solution in methyl acetate. To change the solvent, evaporate the methyl acetate under a gentle stream of nitrogen and immediately add the solvent of choice. PGB2, purged with an inert gas, is soluble in ethanol at ~100 mg/mL, DMSO at ~50 mg/mL and in dimethyl formamide at ~ 75 mg/mL.
signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3
target_organs
Central nervous system
supp_hazards
存储类别
3 - Flammable liquids
wgk
WGK 2
flash_point_f
15.8 °F
flash_point_c
-9 °C
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
新产品
此项目有
R J Heaslip et al.
The Journal of pharmacology and experimental therapeutics, 250(1), 44-51 (1989-07-01)
The effects of prostaglandin (PG) F2 alpha and PGB2 on isolated rat aortic strips were studied in calcium-free 1 mM ethylene glycol bis(beta-aminoethyl ether)-N,N'-tetraacetic acid buffer to explore the mechanisms of PG-induced smooth muscle contraction. In the absence of extracellular
W S Powell et al.
The Journal of biological chemistry, 269(41), 25373-25380 (1994-10-14)
We have shown previously that human neutrophil microsomes contain a highly specific dehydrogenase which, in the presence of NADP+, converts 5S-hydroxy-6,8,11,14-eicosatetraenoic acid (5S-HETE) to its 5-oxo metabolite, 5-oxo-ETE, a potent agonist of these cells. However, intact neutrophils convert 5S-HETE principally
EXTRACT FROM NETTLE SEEDS (URTICA DIOICA L.) DECREASES THE SYNTHESIS OF LIPOXIN Asub 4 THROUGH INHIBITION OF THE DEVELOPMENT OF FLUORIDE-INDUCED INFLAMMATION IN THP1 MONOCYTES/MACROPHAGES
Lukomska A, et al.
Fluoride null
Quantitation of sulfidopeptide leukotrienes by reversed-phase high-performance liquid chromatography.
M Müller et al.
Journal of chromatography, 343(1), 213-218 (1985-09-13)
Sarah F Muldoon et al.
NeuroImage. Clinical, 18, 599-607 (2018-05-31)
Cognitive effort is known to play a role in healthy brain state organization, but little is known about its effects on pathological brain dynamics. When cortical stimulation is used to map functional brain areas prior to surgery, a common unwanted
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