P5390
前列腺素 B2
≥98%, synthetic
别名:
(5Z,13E,15S)-15-Hydroxy-9-oxoprosta-5,8(12),13-trien-1-oic acid, PGB2
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关于此项目
经验公式（希尔记法）:
C20H30O4
化学文摘社编号:
分子量:
334.45
UNSPSC Code:
12352211
NACRES:
NA.77
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
2153006
biological source
synthetic
assay
≥98%
form
solution
solubility
ethanol: ~100 mg/mL, PBS, pH 7.2: ~2 mg/mL, DMSO: ~50 mg/mL
InChI
1S/C20H30O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h4,7,12,14,17,21H,2-3,5-6,8-11,13,15H2,1H3,(H,23,24)/b7-4-,14-12+/t17-/m0/s1
SMILES string
CCCCC[C@H](O)\C=C\C1=C(C\C=C/CCCC(O)=O)C(=O)CC1
InChI key
PRFXRIUZNKLRHM-HKVRTXJWSA-N
storage temp.
−20°C
Quality Level
Application
Prostaglandin B2 has been used as an internal standard in high-performance liquid chromatography (HPLC).
Biochem/physiol Actions
Prostaglandin B2 (PGB2) is an eicosanoid and a lipid mediator. It is synthesized by the dehydration of PGE2. It is a primary prostaglandin associated with the osteoblasts and may induce pulmonary hypertension. PGB2 is also reported to inhibit glucagon stimulated glycogenolysis and forskolin-stimulated adenylate cyclase activity in plasma membranes.
Physical form
Prostaglandin B2 is supplied as a solution in methyl acetate
Preparation Note
PGB2 is provided as a solution in methyl acetate. To change the solvent, evaporate the methyl acetate under a gentle stream of nitrogen and immediately add the solvent of choice. PGB2, purged with an inert gas, is soluble in ethanol at ~100 mg/mL, DMSO at ~50 mg/mL and in dimethyl formamide at ~ 75 mg/mL.
signalword
Danger
hcodes
Hazard Classifications
Eye Irrit. 2 - Flam. Liq. 2 - STOT SE 3
target_organs
Central nervous system
supp_hazards
存储类别
3 - Flammable liquids
wgk
WGK 2
flash_point_f
15.8 °F
flash_point_c
-9 °C
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
法规信息
新产品
此项目有
George Binh Lenon et al.
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Herbal therapies are being used increasingly for the treatment of allergic rhinitis. The aim of this study was to investigate the possible pharmacological actions and cellular targets of a Chinese herbal formula (RCM-101), which was previously shown to be effective
Yurika Otoki et al.
Lipids, 55(1), 7-22 (2019-11-07)
In the brain, approximately 90% of oxylipins are esterified to lipids. However, the significance of this esterification process is not known. In the present study, we (1) validated an aminopropyl solid phase extraction (SPE) method for separating esterified lipids using
L O Eriksson et al.
Acta physiologica Scandinavica, 139(3), 393-404 (1990-07-01)
The prostaglandin E2 (PGE2) binding site in human kidney was characterized in membrane preparations from cortex, outer medulla and inner medulla using radioligand binding techniques. The localization of the binding sites for [3H]PGE2 was visualized autoradiographically. In the membrane suspensions
Omkar Zilka et al.
ACS central science, 3(3), 232-243 (2017-04-08)
Ferroptosis is a form of regulated necrosis associated with the iron-dependent accumulation of lipid hydroperoxides that may play a key role in the pathogenesis of degenerative diseases in which lipid peroxidation has been implicated. High-throughput screening efforts have identified ferrostatin-1
K Büyükgüzel et al.
Insect biochemistry and molecular biology, 32(4), 435-443 (2002-03-12)
We describe prostaglandin (PG) biosynthesis by isolated midgut preparations from tobacco hornworms, Manduca sexta. Microsomal-enriched midgut preparations yielded four PGs, PGA/B(2), PGD(2), PGE(2) and PGF(2alpha), all of which were confirmed by analysis on gas chromatography--mass spectrometry (GC--MS). PGA and PGB
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