Quality Level
InChI key
JXYWFNAQESKDNC-BTJKTKAUSA-N
InChI
1S/C17H23N3O.C4H4O4/c1-19(2)12-13-20(17-6-4-5-11-18-17)14-15-7-9-16(21-3)10-8-15;5-3(6)1-2-4(7)8/h4-11H,12-14H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
SMILES string
OC(=O)\C=C/C(O)=O.COc1ccc(CN(CCN(C)C)c2ccccn2)cc1
form
powder
originator
Watson
Gene Information
human ... HRH1(3269)
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Application
马来酸吡拉明盐已:
- 作为 H 1 受体拮抗剂
- 用于处理仙女水母属,然后被注射到小鼠腹腔,防止在在膜结合试验中有内源性组胺释放,
- 从而测定 K i 值;并在比较抑制浓度 (IC 50 ) 研究中通过全细胞膜片钳技术使用
Biochem/physiol Actions
马来酸吡拉明为 H1 组胺受体拮抗剂。马来酸吡拉明诱导脊椎动物睡眠。在 仙女水母属 中,它诱导浓度依赖性休眠。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
The jellyfish Cassiopea exhibits a sleep-like state
Nath RD, et al.
Current Biology, 27(19), 2984-2990 (2017)
Evaluating Vascular Hyperpermeability-inducing Agents in the Skin with the Miles Assay
Brash JT, et al.
Journal of Visualized Experiments, 27(136), e57524-e57524 (2018)
Physical and biological properties of pyrilamine.
T J Haley
Journal of pharmaceutical sciences, 72(1), 3-12 (1983-01-01)
The [3H] dofetilide binding assay is a predictive screening tool for hERG blockade and proarrhythmia: Comparison of intact cell and membrane preparations and effects of altering [K+] o
Diaz GJ, et al.
Journal of Pharmacological and Toxicological Methods, 50(3), 187-199 (2004)
Zane Stromberga et al.
Scientific reports, 9(1), 3899-3899 (2019-03-09)
The mechanisms underlying bladder contractile disorders such as overactive bladder are not fully understood, and there is limited understanding of the receptor systems modulating spontaneous bladder contractions. We investigated the potential for histamine to have a role in mediating contractility
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