P5624

PD-118057

Name: PD-118057
Brand: SIGMA

≥98% (HPLC), solid

别名:

2-[[4-[2-(3,4-Dichlorophenyl)ethyl]phenyl]amino]benzoic acid

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关于此项目

经验公式（希尔记法）:

C₂₁H₁₇Cl₂NO₂

化学文摘社编号:

313674-97-4

分子量:

386.27

NACRES:

NA.77

PubChem Substance ID:

24724580

UNSPSC Code:

12352200

MDL number:

MFCD08705328

主要文件

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产品名称

PD-118057, ≥98% (HPLC), solid

InChI

1S/C21H17Cl2NO2/c22-18-12-9-15(13-19(18)23)6-5-14-7-10-16(11-8-14)24-20-4-2-1-3-17(20)21(25)26/h1-4,7-13,24H,5-6H2,(H,25,26)

SMILES string

OC(=O)c1ccccc1Nc2ccc(CCc3ccc(Cl)c(Cl)c3)cc2

InChI key

ZCQOSCDABPVAFB-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

solid

color

light yellow

solubility

DMSO: 9 mg/mL

storage temp.

−20°C

Quality Level

100

Biochem/physiol Actions

Activator of ether-a-go-go-related (hERG) potassium channel. Used in the treatment of congestive heart failure.

PD-118057 is an activator of ether-a-go-go-related (hERG) potassium channel. PD-118057 is a second identified hERG channel activator, a representative in the series of structural analogs; PD-118057 at 10 μM leads to a 111% current increase in rabbit ventricular wedge (in comparison RPR260243 leads to only a 15% increase at the same concentration);PD-118057, unlike RPR260243, does not have a major effect on gating or kinetic properties of this channel. PD-118057prevents and reverses QT interval prolongation; Compounds such as PD-118057 may offer new approach in the treatment of delayed repolarization conditions, which occur in inherited or acquired long QT syndrome and congestive heart failure

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.