P5640
前列腺素E2
≥93% (HPLC), synthetic
别名:
(5Z,11α,13E,15S)-11,15-二羟基-9-酮前列-5,13-二烯酸, PGE2, 地诺前列酮
选择尺寸
关于此项目
biological source
synthetic
Quality Segment
assay
≥93% (HPLC)
form
powder
functional group
carboxylic acid, hydroxyl
shipped in
ambient
storage temp.
−20°C
SMILES string
O[C@@H]1CC([C@H](C/C=C\CCCC(O)=O)[C@H]1/C=C/[C@@H](O)CCCCC)=O
InChI
1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1
InChI key
XEYBRNLFEZDVAW-ARSRFYASSA-N
Gene Information
human ... PTGER1(5731), PTGER2(5732), PTGER3(5733), PTGER4(5734), PTGIR(5739)
mouse ... Ptger1(19216), Ptger2(19217), Ptger3(19218), Ptger4(19219)
Application
- 在肺炎球菌肺炎小鼠模型中，消退后巨噬细胞塑造长期组织免疫和完整性。本研究调查了前列腺素E2在炎症消退阶段的影响，证明了它在细菌性肺部感染后巨噬细胞介导的组织修复和免疫记忆中的重要作用，为免疫系统调节和恢复过程提供了深入见解（Feehan et al., 2024）。
Biochem/physiol Actions
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Repr. 1B
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges