biological source
bovine nasal septum
form
powder
technique(s)
cell culture | stem cell: suitable
UniProt accession no.
storage temp.
−20°C
Quality Level
Gene Information
bovine ... PRG4(280867)
General description
蛋白聚糖由核心蛋白组成，糖胺聚糖链与核心蛋白共价连接。它们存在于许多器官和组织中，并在脊椎动物软骨基质中大量存在。蛋白聚糖位于许多细胞的细胞外和细胞周基质中。
Application
牛鼻中隔蛋白多糖含有86%的硫酸软骨素，已用于体外研究硫酸软骨素蛋白多糖的作用。已经证明它可以促进培养物中神经干细胞的存活。
牛鼻中隔蛋白聚糖已被用于诱导小鼠关节炎。
Biochem/physiol Actions
蛋白聚糖参与组织结构，促进细胞生长和专门的组织成熟。它们起到生物过滤器的作用，调节胶原纤维的生成、皮肤拉伸强度和神经炎的生长。蛋白聚糖还参与调节生长因子的活性，影响肿瘤细胞的生长和侵袭，并促进角膜透明。
Preparation Note
通过改良的Antonopoulos程序，在DEAE-纤维素上使用7M尿素进行色谱纯化。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
监管及禁止进口产品
此项目有
Muly Tham et al.
PloS one, 5(12), e15341-e15341 (2010-12-24)
Understanding how autocrine/paracrine factors regulate neural stem cell (NSC) survival and growth is fundamental to the utilization of these cells for therapeutic applications and as cellular models for the brain. In vitro, NSCs can be propagated along with neural progenitors
Antonopoulos, C.A.
Biochimica et Biophysica Acta, 338, 108-119 (1974)
M Kopec et al.
Scientific reports, 9(1), 166-166 (2019-01-19)
We have shown that Raman microspectroscopy is a powerful method for visualization of glycocalyx offering cellular interrogation without staining, unprecedented spatial and spectral resolution, and biochemical information. We showed for the first time that Raman imaging can be used to
商品
Glycosaminoglycans are large linear polysaccharides constructed of repeating disaccharide units.
Uncover more about glycosaminoglycans and proteoglycans including the structure of glycosaminoglycans (GAGs), the different types of GAGs, and their functions.
有五种已发现的糖胺聚糖链（参见图1）透明质酸不是硫酸化的，但其他糖胺聚糖链在链的不同位置含有硫酸根取代基。
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