P6102
Anti-Potassium Channel Kir2.1 antibody produced in rabbit
affinity isolated antibody, lyophilized powder
别名:
Anti-ATFB9, Anti-HHBIRK1, Anti-HHIRK1, Anti-IRK1, Anti-KIR2.1, Anti-LQT7, Anti-SQT3
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关于此项目
Conjugate:
unconjugated
Clone:
polyclonal
Application:
immunohistochemistry
western blot (chemiluminescent)
western blot (chemiluminescent)
Species reactivity:
rat
Citations:
5
Technique(s):
immunohistochemistry: suitable
western blot (chemiluminescent): 1:200
western blot (chemiluminescent): 1:200
Uniprot accession no.:
产品名称
Anti-Potassium Channel Kir2.1 antibody produced in rabbit, affinity isolated antibody, lyophilized powder
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
lyophilized powder
species reactivity
rat
technique(s)
immunohistochemistry: suitable
western blot (chemiluminescent): 1:200
UniProt accession no.
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... KCNJ2(3759)
mouse ... Kcnj2(16518)
rat ... Kcnj2(29712)
Biochem/physiol Actions
Potassium voltage-gated channel subfamily J member 2 (KCNJ2) has been shown to have a role in the differentiation and proliferation of bone marrow-derived macrophages (BMDM) in mice. It allows the inward movement of K+ into the cell and maintains its balance. Mutations in the KCNJ2 gene have been linked to Andersen-Tawil syndrome.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Potassium voltage-gated channel subfamily J member 2 (KCNJ2) is an inward-rectifying potassium channel. This tetrameric protein possesses two transmembrane helix domains (M1 and M2), an ion-selective P-loop between M1 and M2 and cytoplasmic amino and carboxy-terminal domains. The gene encoding KCNJ2 is localized on human chromosome 17q24.3.
Immunogen
synthetic peptide corresponding to amino acids 392-410 of human Kir2.1 (with additional N-terminal cysteine). This epitope is identical in rabbit, bovine, pig, and guinea pig and highly homologous in rat, mouse and chicken.
Physical form
Lyophilized from phosphate buffered saline, pH 7.4, 1% bovine serum albumin, and 0.025% sodium azide.
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Warning
hcodes
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Aquatic Chronic 3
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
含少量动物源组分生物产品
常规特殊物品
此项目有
Genome-wide association study identifies a susceptibility locus for thyrotoxic periodic paralysis at 17q24.3
Ching-Lung C
Nature Genetics (2012)
Upregulation of the inwardly rectifying potassium channel Kir2.1 (KCNJ2) modulates multidrug resistance of small-cell lung cancer under the regulation of miR-7 and the Ras/MAPK pathway
Huanxin Liu
Molecular Cancer (2015)
Role of Kir2.1 in human monocyte-derived foam cell maturation
Wei Zhang
Journal of Cellular and Molecular Medicine (2016)
Association of KCNJ2 Genetic Variants with Susceptibility to Thyrotoxic Periodic Paralysis in Patients with Graves' Disease.
Park S
Experimental and Clinical Endocrinology & Diabetes (2017)
Novel mutation in the KCNJ2 gene is associated with a malignant arrhythmic phenotype of Andersen-Tawil syndrome.
Fernlund E
Annals of Noninvasive Electrocardiology : The Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc (2013)
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