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Merck
CN

P6188

前列腺素 I2 钠盐

≥96% (HPLC), synthetic, powder

别名:

PGI2-钠, 依前列醇 钠盐, 前列环素 钠盐, （5Z,9 & # 945;,11 & # 945;,13E,15S）-6,9-环氧-11,15-二羟基前列腺素-5,13-迪恩-1-oic酸 钠盐

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关于此项目

经验公式（希尔记法）:
C20H31NaO5
化学文摘社编号:
61849-14-7
分子量:
374.45
PubChem Substance ID:
24898653
eCl@ss:
42020658
UNSPSC Code:
12352401
NACRES:
NA.77
EC Number:
263-273-7
Beilstein/REAXYS Number:
6472195

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产品名称

前列腺素 I2 钠盐, ≥96% (HPLC), synthetic, powder

InChI key

OURCVRVJQMLUNA-QFDVFERUSA-M

InChI

1S/C20H32O5.Na/c1-2-3-4-8-15(21)10-11-16-17(22)12-18-20(16)14(13-25-18)7-5-6-9-19(23)24;/h7,10-11,15-18,20-22H,2-6,8-9,12-13H2,1H3,(H,23,24);/q;+1/p-1/b11-10+,14-7-;/t15-,16-,17+,18-,20+;/m0./s1

SMILES string

CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C[C@@](O/2)([H])[C@]1([H])CC2=C\CCCC(O)=O.[Na]

biological source

synthetic

assay

≥96% (HPLC)

form

powder

color

white to off-white

solubility

H2O: 1 mg/mL (Hydrolyzes to 6-ketoprostaglandin F1α in aqueous solution.)
ethanol: 50 mg/mL

functional group

carboxylic acid
hydroxyl

shipped in

ambient

storage temp.

−20°C

Quality Level

200

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相关类别

Application

前列腺素I2钠盐已用于以下情形：
  • 制备储备溶液，用于血小板洗涤程序
  • 在富血小板血浆中用作补充剂，用于血小板制剂
  • 防止血小板激活

Biochem/physiol Actions

前列环素是血管内皮细胞中环氧合酶途径的一种短期产物。通过拮抗血栓烷A2和刺激血小板腺苷酸环化酶，用作血小板聚集的有效抑制剂。一氧化氮也在血管内皮中产生，抑制血小板聚集，调节诱导型环氧合酶的产生，并可与前列环素协同作用以减弱血栓形成过程。前列环素具有血管保护作用，保护动脉壁免受损伤引起的损伤，并保护肝脏和胃肠道的细胞。
前列环素治疗改善肺动脉高压的血流动力学。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000445997
0000445997
0000433918
0000433918
0000357901

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G J Dusting et al.
Clinical and experimental pharmacology & physiology. Supplement, 25, S34-S41 (1998-11-11)
1. Nitric oxide (NO) has important roles in physiological vasodilatation, cytotoxicity and vascular disease. Nitric oxide and prostacyclin (PGI2), both released from the endothelium, act synergistically to inhibit platelet aggregation and adhesion. These autacoids also inhibit the adhesion and migration
Anna-Karin Larsson-Callerfelt et al.
Respiratory research, 14, 21-21 (2013-02-15)
Prostacyclin analogs are potent vasodilators and possess anti-inflammatory properties. However, the effect of prostacyclin on extracellular matrix (ECM) in COPD is not well known. Collagen fibrils and proteoglycans are essential ECM components in the lung and fibroblasts are key players
Seung-Jae Joo et al.
Korean circulation journal, 45(5), 378-385 (2015-09-29)
Residual platelet reactivity in patients who are taking clopidogrel is commonly measured with VerifyNow assay, which is based on the principle of light transmission aggregometry. However, to evaluate the residual platelet reactivity, it would be more accurate if the reactivity
Paola Vitale et al.
Journal of medicinal chemistry, 56(11), 4277-4299 (2013-05-09)
3-(5-Chlorofuran-2-yl)-5-methyl-4-phenylisoxazole (P6), a known selective cyclooxygenase-1 (COX-1) inhibitor, was used to design a new series of 3,4-diarylisoxazoles in order to improve its biochemical COX-1 selectivity and antiplatelet efficacy. Structure-activity relationships were studied using human whole blood assays for COX-1 and
Y Numaguchi et al.
Arteriosclerosis, thrombosis, and vascular biology, 19(3), 727-733 (1999-03-12)
Prostacyclin (PGI2), a metabolite of arachidonic acid, has the vasoprotective effects of vasodilation, anti-platelet aggregation, and inhibition of smooth muscle cell proliferation. We hypothesized that an overexpression of endogenous PGI2 may accelerate the recovery from endothelial damage and inhibit neointimal
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