Merck
CN

P6188

Sigma-Aldrich

前列腺素 I2 钠盐

≥96% (HPLC), synthetic, powder

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别名:
PGI2-钠, 依前列醇 钠盐, 前列环素 钠盐, (5Z,9 & # 945;,11 & # 945;,13E,15S)-6,9-环氧-11,15-二羟基前列腺素-5,13-迪恩-1-oic酸 钠盐
Empirical Formula (Hill Notation):
C20H31NaO5
CAS号:
分子量:
374.45
Beilstein:
6472195
EC 号:
eCl@ss:
42020658
PubChem化学物质编号:
NACRES:
NA.77

生物来源

synthetic

质量水平

检测方案

≥96% (HPLC)

形式

powder

颜色

white to off-white

溶解性

H2O: 1 mg/mL (Hydrolyzes to 6-ketoprostaglandin F in aqueous solution.)
ethanol: 50 mg/mL

官能团

carboxylic acid
hydroxyl

运输

ambient

储存温度

−20°C

SMILES string

CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C[C@@](O/2)([H])[C@]1([H])CC2=C\CCCC(O)=O.[Na]

InChI

1S/C20H32O5.Na/c1-2-3-4-8-15(21)10-11-16-17(22)12-18-20(16)14(13-25-18)7-5-6-9-19(23)24;/h7,10-11,15-18,20-22H,2-6,8-9,12-13H2,1H3,(H,23,24);/q;+1/p-1/b11-10+,14-7-;/t15-,16-,17+,18-,20+;/m0./s1

InChI key

OURCVRVJQMLUNA-QFDVFERUSA-M

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此商品
P5640P0424P5069
Prostaglandin I2 sodium salt ≥96% (HPLC), synthetic, powder

Sigma-Aldrich

P6188

前列腺素 I2 钠盐

Prostaglandin E2 ≥93% (HPLC), synthetic

Sigma-Aldrich

P5640

前列腺素E2

assay

≥96% (HPLC)

assay

≥93% (HPLC)

assay

≥99%

assay

≥99%

form

powder

form

powder

form

powder

form

powder

color

white to off-white

color

-

color

white

color

-

solubility

H2O: 1 mg/mL (Hydrolyzes to 6-ketoprostaglandin F in aqueous solution.), ethanol: 50 mg/mL

solubility

-

solubility

H2O: 1 mg/mL (Aqueous solutions are stable for 30 days at 2-8°C and for several months frozen at −0°C in single use aliquots. Avoid repeated freeze/thaw cycles.), ethanol: 50 mg/mL

solubility

ethanol: 50 mg/mL, clear, colorless

functional group

carboxylic acid, hydroxyl

functional group

carboxylic acid, hydroxyl

functional group

carboxylic acid, hydroxyl

functional group

-

应用

前列腺素I2钠盐已用于以下情形:
  • 制备储备溶液,用于血小板洗涤程序
  • 在富血小板血浆中用作补充剂,用于血小板制剂
  • 防止血小板激活

生化/生理作用

前列环素是血管内皮细胞中环氧合酶途径的一种短期产物。通过拮抗血栓烷A2和刺激血小板腺苷酸环化酶,用作血小板聚集的有效抑制剂。一氧化氮也在血管内皮中产生,抑制血小板聚集,调节诱导型环氧合酶的产生,并可与前列环素协同作用以减弱血栓形成过程。前列环素具有血管保护作用,保护动脉壁免受损伤引起的损伤,并保护肝脏和胃肠道的细胞。
前列环素治疗改善肺动脉高压的血流动力学。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves


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