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Merck
CN

P6188

Sigma-Aldrich

前列腺素 I2 钠盐

≥96% (HPLC), synthetic, powder

别名:

PGI2-钠, 依前列醇 钠盐, 前列环素 钠盐, （5Z,9 & # 945;,11 & # 945;,13E,15S）-6,9-环氧-11,15-二羟基前列腺素-5,13-迪恩-1-oic酸 钠盐

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关于此项目

经验公式（希尔记法）:
C20H31NaO5
CAS Number:
61849-14-7
分子量:
374.45
Beilstein:
6472195
EC 号:
263-273-7
UNSPSC代码:
12352401
eCl@ss:
42020658
PubChem化学物质编号:
24898653
NACRES:
NA.77

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生物来源

synthetic

质量水平

200

方案

≥96% (HPLC)

表单

powder

颜色

white to off-white

溶解性

H2O: 1 mg/mL (Hydrolyzes to 6-ketoprostaglandin F1α in aqueous solution.)
ethanol: 50 mg/mL

官能团

carboxylic acid
hydroxyl

运输

ambient

储存温度

−20°C

SMILES字符串

CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C[C@@](O/2)([H])[C@]1([H])CC2=C\CCCC(O)=O.[Na]

InChI

1S/C20H32O5.Na/c1-2-3-4-8-15(21)10-11-16-17(22)12-18-20(16)14(13-25-18)7-5-6-9-19(23)24;/h7,10-11,15-18,20-22H,2-6,8-9,12-13H2,1H3,(H,23,24);/q;+1/p-1/b11-10+,14-7-;/t15-,16-,17+,18-,20+;/m0./s1

InChI key

OURCVRVJQMLUNA-QFDVFERUSA-M

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相关类别

应用

前列腺素I2钠盐已用于以下情形：
  • 制备储备溶液，用于血小板洗涤程序
  • 在富血小板血浆中用作补充剂，用于血小板制剂
  • 防止血小板激活

生化/生理作用

前列环素是血管内皮细胞中环氧合酶途径的一种短期产物。通过拮抗血栓烷A2和刺激血小板腺苷酸环化酶，用作血小板聚集的有效抑制剂。一氧化氮也在血管内皮中产生，抑制血小板聚集，调节诱导型环氧合酶的产生，并可与前列环素协同作用以减弱血栓形成过程。前列环素具有血管保护作用，保护动脉壁免受损伤引起的损伤，并保护肝脏和胃肠道的细胞。
前列环素治疗改善肺动脉高压的血流动力学。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000445997
0000445997
0000433918
0000433918
0000357901

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D Salvemini
Cellular and molecular life sciences : CMLS, 53(7), 576-582 (1997-07-01)
Nitric oxide (NO), derived from L-arginine (L-Arg) by the enzyme nitric oxide synthase (NOS) is involved in the regulation of several important physiological and pathophysiological functions. The mechanisms by which NO exerts some of its beneficial or detrimental effects include
Vijayakumar Chinnathambi et al.
Hypertension (Dallas, Tex. : 1979), 61(3), 647-654 (2013-01-23)
Sex steroid hormones estradiol and progesterone play an important role in vascular adaptations during pregnancy. However, little is known about the role of androgens. Plasma testosterone (T) levels are elevated in preeclampsia, mothers with polycystic ovary, and pregnant African American
Anna-Karin Larsson-Callerfelt et al.
Respiratory research, 14, 21-21 (2013-02-15)
Prostacyclin analogs are potent vasodilators and possess anti-inflammatory properties. However, the effect of prostacyclin on extracellular matrix (ECM) in COPD is not well known. Collagen fibrils and proteoglycans are essential ECM components in the lung and fibroblasts are key players
G J Dusting et al.
Clinical and experimental pharmacology & physiology. Supplement, 25, S34-S41 (1998-11-11)
1. Nitric oxide (NO) has important roles in physiological vasodilatation, cytotoxicity and vascular disease. Nitric oxide and prostacyclin (PGI2), both released from the endothelium, act synergistically to inhibit platelet aggregation and adhesion. These autacoids also inhibit the adhesion and migration
Y Numaguchi et al.
Arteriosclerosis, thrombosis, and vascular biology, 19(3), 727-733 (1999-03-12)
Prostacyclin (PGI2), a metabolite of arachidonic acid, has the vasoprotective effects of vasodilation, anti-platelet aggregation, and inhibition of smooth muscle cell proliferation. We hypothesized that an overexpression of endogenous PGI2 may accelerate the recovery from endothelial damage and inhibit neointimal
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