InChI key
NIJJYAXOARWZEE-UHFFFAOYSA-N
InChI
1S/C8H16O2/c1-3-5-7(6-4-2)8(9)10/h7H,3-6H2,1-2H3,(H,9,10)
SMILES string
CCCC(C(O)=O)CCC
refractive index
n20/D 1.425 (lit.)
bp
220 °C (lit.)
solubility
H2O: slightly soluble
alcohol: soluble
density
0.9 g/mL at 25 °C (lit.)
lipid type
saturated FAs
Quality Level
Gene Information
human ... ALDH5A1(7915), CYP1A2(1544)
mouse ... Hdac1(433759)
rat ... Slc6a1(79212)
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Application
2-丙基戊酸作为补充剂，用于小鼠胚胎成纤维细胞条件培养基（MEF-CM），培养细胞。
Biochem/physiol Actions
2-丙基戊酸是短链脂肪酸，或能抑制组蛋白去乙酰化酶的作用。可促进肿瘤细胞毒性，增加对辐射的敏感性。2-丙基戊酸可提高大脑中 γ-氨基丁酸水平。 存在过量2-丙基戊酸，则可观察到中枢神经系统作用减弱。它通过阻断电压依赖性钠通道，增强 γ-氨基丁酸（GABA）的抑制作用。
抗惊厥药，同时还具有双相障碍症情绪稳定剂的功效
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1 - Repr. 1A - Skin Irrit. 2
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
231.8 °F - closed cup
flash_point_c
111 °C - closed cup
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
3-Heptanone as a potential new marker for valproic acid therapy
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Journal of Breath Research, 3(1), 016004-016004 (2009)
Efficient generation of nonhuman primate induced pluripotent stem cells
Zhong B, et al.
Stem Cells and Development, 20(5), 795-807 (2010)
Histone deacetylase inhibitor, 2-propylpentanoic acid, increases the chemosensitivity and radiosensitivity of human glioma cell linesin vitro
Cuijie S, et al.
Chinese Medical Journal (English Edition), 125(24), 4338-4343 (2012)
Xi Chen et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(21), 9202-9213 (2013-05-24)
Progranulin (PGRN) is a secreted glycoprotein expressed in neurons and glia that is implicated in neuronal survival on the basis that mutations in the GRN gene causing haploinsufficiency result in a familial form of frontotemporal dementia (FTD). Recently, a direct
Jakob Christensen et al.
JAMA, 309(16), 1696-1703 (2013-04-25)
Valproate is used for the treatment of epilepsy and other neuropsychological disorders and may be the only treatment option for women of childbearing potential. However, prenatal exposure to valproate may increase the risk of autism. To determine whether prenatal exposure
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