P6656
普马嗪 盐酸盐
别名:
10-(3-二甲基氨丙基)吩噻嗪 盐酸盐
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线性分子式:
C17H20N2S · HCl
化学文摘社编号:
分子量:
320.88
UNSPSC Code:
41116107
NACRES:
NA.77
PubChem Substance ID:
EC Number:
200-179-7
Beilstein/REAXYS Number:
3753230
MDL number:
InChI key
JIVSXRLRGOICGA-UHFFFAOYSA-N
InChI
1S/C17H20N2S.ClH/c1-18(2)12-7-13-19-14-8-3-5-10-16(14)20-17-11-6-4-9-15(17)19;/h3-6,8-11H,7,12-13H2,1-2H3;1H
SMILES string
Cl[H].CN(C)CCCN1c2ccccc2Sc3ccccc13
form
solid
originator
Baxter
storage temp.
2-8°C
Gene Information
human ... DRD2(1813), DRD3(1814), DRD4(1815), HTR2A(3356)
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Application
Promazine hydrochloride has been used in conductivity and surface tension measurements and for testing inhibition of feline coronavirus (FCoV) in Felis catus whole fetus-4 (fcwf-4) cells.
Biochem/physiol Actions
D2 dopamine receptor antagonist; phenothiazine antipsychotic.
Features and Benefits
This compound was developed by Baxter. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
General description
Promazine hydrochloride (PMZ) belongs to the phenothiazine drug family. Promazine is a D2 dopamine receptor antagonist and has antipsychotic and anticholinergic functionality. It is used for pain management and is also used for treating hypersensitivity reactions.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Skin Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Study of the interaction between promazine hydrochloride and surfactant (conventional/gemini) mixtures at different temperatures.
Rub MA, et al.
Journal of Solution Chemistry, 43(5), 930-949 (2014)
Promazine in the treatment of delusional parasitosis.
Cubala W, et al.
Psychiatria Danubina, 23(2.), 198-199 (2011)
Determination of thiazinamium, promazine and promethazine in pharmaceutical formulations using a CZE method.
Lara FJ, et al.
Analytica Chimica Acta, 535(1-2), 101-108 (2005)
W A Daniel et al.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 9(4), 337-344 (1999-07-28)
The aim of the present study was to investigate a possible impact of the three selective serotonin reuptake inhibitors (SSRIs) fluoxetine, fluvoxamine and sertraline on the pharmacokinetics of promazine in a steady state in rats. Promazine was administered twice a
Synergistic antiviral effect of Galanthus nivalis agglutinin and nelfinavir against feline coronavirus.
Hsieh LE, et al.
Antiviral Research, 88(1), 25-30 (2010)
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