P6656
普马嗪 盐酸盐
别名:
10-(3-二甲基氨丙基)吩噻嗪 盐酸盐
表单
solid
创始人
Baxter
储存温度
2-8°C
SMILES字符串
Cl[H].CN(C)CCCN1c2ccccc2Sc3ccccc13
InChI
1S/C17H20N2S.ClH/c1-18(2)12-7-13-19-14-8-3-5-10-16(14)20-17-11-6-4-9-15(17)19;/h3-6,8-11H,7,12-13H2,1-2H3;1H
InChI key
JIVSXRLRGOICGA-UHFFFAOYSA-N
基因信息
human ... DRD2(1813), DRD3(1814), DRD4(1815), HTR2A(3356)
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一般描述
Promazine hydrochloride (PMZ) belongs to the phenothiazine drug family. Promazine is a D2 dopamine receptor antagonist and has antipsychotic and anticholinergic functionality. It is used for pain management and is also used for treating hypersensitivity reactions.
应用
Promazine hydrochloride has been used in conductivity and surface tension measurements and for testing inhibition of feline coronavirus (FCoV) in Felis catus whole fetus-4 (fcwf-4) cells.
生化/生理作用
D2 dopamine receptor antagonist; phenothiazine antipsychotic.
特点和优势
This compound was developed by Baxter. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral - Skin Sens. 1
储存分类代码
11 - Combustible Solids
WGK
WGK 3
个人防护装备
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Promazine in the treatment of delusional parasitosis.
Cubala W, et al.
Psychiatria Danubina, 23(2.), 198-199 (2011)
Determination of thiazinamium, promazine and promethazine in pharmaceutical formulations using a CZE method.
Lara FJ, et al.
Analytica Chimica Acta, 535(1-2), 101-108 (2005)
Synergistic antiviral effect of Galanthus nivalis agglutinin and nelfinavir against feline coronavirus.
Hsieh LE, et al.
Antiviral Research, 88(1), 25-30 (2010)
W A Daniel et al.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 9(4), 337-344 (1999-07-28)
The aim of the present study was to investigate a possible impact of the three selective serotonin reuptake inhibitors (SSRIs) fluoxetine, fluvoxamine and sertraline on the pharmacokinetics of promazine in a steady state in rats. Promazine was administered twice a
Li-En Hsieh et al.
Antiviral research, 88(1), 25-30 (2010-07-07)
Feline infectious peritonitis (FIP) is a fatal disease in domestic and nondomestic felids caused by feline coronavirus (FCoV). Currently, no effective vaccine is available for the prevention of this disease. In searching for agents that may prove clinically effective against
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