P6740
17-苯基-三-去甲前列腺素 F 2α-乙酰胺
≥95%, solid
别名:
比马前列素
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关于此项目
经验公式（希尔记法）:
C25H37NO4
化学文摘社编号:
分子量:
415.57
MDL编号:
UNSPSC代码:
12352211
PubChem化学物质编号:
NACRES:
NA.77
质量水平
方案
≥95%
表单
solid
储存温度
−20°C
SMILES字符串
CCNC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1\C=C\[C@@H](O)CCc2ccccc2
InChI
1S/C25H37NO4/c1-2-26-25(30)13-9-4-3-8-12-21-22(24(29)18-23(21)28)17-16-20(27)15-14-19-10-6-5-7-11-19/h3,5-8,10-11,16-17,20-24,27-29H,2,4,9,12-15,18H2,1H3,(H,26,30)/b8-3-,17-16+/t20-,21+,22+,23-,24+/m0/s1
InChI key
AQOKCDNYWBIDND-FTOWTWDKSA-N
基因信息
human ... PTGFR(5737)
应用
强效 FP 前列腺素受体激动剂在青光眼动物模型中的应用。
警示用语：
Danger
危险声明
危险分类
Acute Tox. 4 Oral - Repr. 1B
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Hong Liang et al.
PloS one, 7(3), e33913-e33913 (2012-03-24)
Conjunctiva-associated lymphoid tissue (CALT) is closely associated with ocular surface immunity. This study investigated the effects of antiglaucoma prostaglandin analogs with or without benzalkonium chloride (BAK) preservative on organized CALT using an acute toxic model. A total of 48 albino
Monika Yadav et al.
Materials science & engineering. C, Materials for biological applications, 103, 109730-109730 (2019-07-28)
Primary treatment for glaucoma relies on chronic instillation (daily) of intraocular pressure (IOP) lowering eye drops. Present study tends to develop and assess a novel sustained release bimatoprost loaded nanovesicular (BMT-NV) - thermosensitive in-situ gelling implant (BMT-NV-GEL-IM), for subconjunctival delivery.
Jennifer R Seal et al.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics, 35(1), 50-57 (2018-10-20)
To explore the ocular distribution of bimatoprost after intracameral administration of a biodegradable sustained-release bimatoprost implant (Bimatoprost SR) versus repeated topical administration of bimatoprost 0.03% ophthalmic solution in dogs. Bimatoprost SR and topical bimatoprost 0.03% previously were shown to have
Marilita M Moschos et al.
Drug design, development and therapy, 10, 3977-3981 (2016-12-21)
The aim of this study was to investigate the effect of different prostaglandin analogs on platelet-activating factor (PAF) levels. Three prostaglandin analogs were selected: bimatoprost 0.3 mg/mL, latanoprost 50 μg/mL, and tafluprost 15 μg/mL. Each drug sample was tested for
M Abramovitz et al.
Biochimica et biophysica acta, 1483(2), 285-293 (2000-01-15)
Stable cell lines that individually express the eight known human prostanoid receptors (EP(1), EP(2), EP(3), EP(4), DP, FP, IP and TP) have been established using human embryonic kidney (HEK) 293(EBNA) cells. These recombinant cell lines have been employed in radioligand
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