P6775
Palmitoleoyl coenzyme A lithium salt
~90%
别名:
cis-9-Hexadecenoyl Coenzyme A
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关于此项目
经验公式（希尔记法）:
C37H64N7O17P3S
化学文摘社编号:
分子量:
1003.93
NACRES:
NA.51
PubChem Substance ID:
UNSPSC Code:
41106305
MDL number:
产品名称
Palmitoleoyl coenzyme A lithium salt, ~90%
InChI
1S/C37H64N7O17P3S/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-28(46)65-21-20-39-27(45)18-19-40-35(49)32(48)37(2,3)23-58-64(55,56)61-63(53,54)57-22-26-31(60-62(50,51)52)30(47)36(59-26)44-25-43-29-33(38)41-24-42-34(29)44/h9-10,24-26,30-32,36,47-48H,4-8,11-23H2,1-3H3,(H,39,45)(H,40,49)(H,53,54)(H,55,56)(H2,38,41,42)(H2,50,51,52)/b10-9+
SMILES string
([Li].C(CCCCCCC\C=C/CCCCCC)(=O)SCCNC(CCNC([C@@H](C(COP(OP(OC[C@@H]1[C@H]([C@H]([C@@H](O1)N1C=NC=2C(N)=NC=NC12)O)OP(=O)(O)O)(=O)O)(=O)O)(C)C)O)=O)=O)
InChI key
QBYOCCWNZAOZTL-MDZDMXLPSA-N
assay
~90%
form
powder
storage temp.
−20°C
Quality Level
Application
Coenzyme A functions as an acyl group carrier, acetyl-CoA. Palmitoleoyl coenzyme A (Palmitoleoyl-CoA) may be used in comparative long chain fatty acyl-CoA studies such as the effects of long-chain acyl-coenzyme A esters on cardiac K(ATP) channels and lipotoxic footprinting.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
G X Liu et al.
Circulation research, 88(9), 918-924 (2001-05-23)
ATP-sensitive K (K(ATP)) channels are inhibited by cytosolic ATP, a defining property that implicitly links these channels to cellular metabolism. Here we report a direct link between fatty acid metabolism and K(ATP) channels in cardiac muscle cells. Long-chain (LC) acyl-coenzyme
Dirk Schulze et al.
The Journal of physiology, 552(Pt 2), 357-367 (2003-10-17)
Phosphatidylinositol phosphates (PIPs, e.g. PIP2) and long-chain acyl-CoA esters (e.g. oleoyl-CoA) are potent activators of KATP channels that are thought to link KATP channel activity to the cellular metabolism of PIPs and fatty acids. Here we show that the two
Makoto Miyazaki et al.
Prostaglandins, leukotrienes, and essential fatty acids, 68(2), 113-121 (2003-01-23)
Stearoyl-CoA desaturase (SCD) (EC 1.14.99.5) is an endoplasmic reticulum-bound enzyme that catalyzes the delta9-cis desaturation of saturated fatty acyl-CoAs, the preferred substrates being palmitoyl- and stearoyl-CoA, which are converted to palmitoleoyl- and oleoyl-CoA, respectively. These monounsaturated fatty acids are used
Romain Harmancey et al.
Journal of lipid research, 51(6), 1380-1393 (2010-01-23)
The "lipotoxic footprint" of cardiac maladaptation in diet-induced obesity is poorly defined. We investigated how manipulation of dietary lipid and carbohydrate influenced potential lipotoxic species in the failing heart. In Wistar rats, contractile dysfunction develops at 48 weeks on a
Regina Ensenauer et al.
The Journal of biological chemistry, 280(37), 32309-32316 (2005-07-16)
Unsaturated fatty acids play an important role in the prevention of human diseases such as diabetes, obesity, cancer, and neurodegeneration. However, their oxidation in vivo by acyl-CoA dehydrogenases (ACADs) that catalyze the first step of each cycle of mitochondrial fatty
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