P6871
Anti-PRMT1 antibody produced in rabbit
~1 mg/mL, affinity isolated antibody, buffered aqueous solution
别名:
Anti-Protein Arginine Methyl Transferase 1 (NQ-15)
登录 查看组织和合同定价。
选择尺寸
关于此项目
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ARR, IF, WB
Citations:
5
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen ~42 kDa
species reactivity
human
concentration
~1 mg/mL
technique(s)
indirect immunofluorescence: 2.5-5.0 μg/mL using paraformaldehyde-fixed 293T cells, microarray: suitable, western blot: 0.25-0.5 μg/mL using 293T cell extracts
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... PRMT1(3276)
mouse ... Prmt1(15469)
General description
PRMT1 belongs to the family of protein arginine methyl transferases (PRMT). These enzymes transfer the methyl group from S-adenosyl-L methionine to the guanidino nitrogen atoms of an arginine residue. PRMTs are divided in two major types, I and II. It is also known as HRMT1L2 and IR1B4. PRMT1 was isolated through its interaction with BTG1 and TIS2, proteins that are important in cell quiescence. It is a 361 amino acids protein; its splicing variants differ at the N-terminus, giving rise to three isoforms (variants 1, 2 and 3).
Immunogen
synthetic peptide corresponding to amino acids 326-341 of mouse PRMT1, conjugated to KLH via an N-terminal added cysteine residue. The sequence is conserved in human, and differs by one amino acid from the rat sequence.
Application
Anti-PRMT1 antibody produced in rabbit has been used in immunoblotting.
Biochem/physiol Actions
PRMT type 1 and 2 catalyze the formation of monomethylarginine, but differs in that Type I (including PRMT1, 3, 4, and 6) catalyzes the formation of asymmetric dimethylarginine, whereas type II (PRMT5) catalyzes the formation of symmetric dimethylarginine.
Physical form
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
未找到合适的产品？
试试我们的产品选型工具.
存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
此项目有
PRMT1 promotes mitosis of cancer cells through arginine methylation of INCENP
Deng X, et al.
Oncotarget, 6(34), 35173-35173 (2015)
Lipopolysaccharide-induced methylation of HuR, an mRNA-stabilizing protein, by CARM1
Li H, et al.
The Journal of biological chemistry, 277(47), 44623-44630 (2002)
The novel human protein arginine N-methyltransferase PRMT6 is a nuclear enzyme displaying unique substrate specificity.
Frankel A
The Journal of Biological Chemistry, 277(5), 3537-3543 (2002)
Prmt5, which forms distinct homo-oligomers, is a member of the protein-arginine methyltransferase family
Rho J, et al.
The Journal of biological chemistry, 276(14), 11393-11401 (2001)
Xiaolan Deng et al.
Oncotarget, 6(34), 35173-35182 (2015-10-16)
Inner centromere protein (INCENP) is a part of a protein complex known as the chromosomal passenger complex (CPC) that is essential for correcting non-bipolar chromosome attachments and for cytokinesis. We here demonstrate that a protein arginine methyltransferase PRMT1, which are
相关内容
Datasheet
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持