P7262
白花丹素 来源于紫雪花
别名:
5-羟基-2-甲基-1,4-萘醌
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关于此项目
经验公式（希尔记法）:
C11H8O3
化学文摘社编号:
分子量:
188.18
NACRES:
NA.79
PubChem Substance ID:
UNSPSC Code:
12352205
EC Number:
207-569-6
MDL number:
InChI key
VCMMXZQDRFWYSE-UHFFFAOYSA-N
InChI
1S/C11H8O3/c1-6-5-9(13)10-7(11(6)14)3-2-4-8(10)12/h2-5,12H,1H3
SMILES string
CC1=CC(C2=C(C1=O)C=CC=C2O)=O
biological source
Plumbago indica
form
powder
color
faint orange to dark orange
mp
76-78 °C (lit.)
storage temp.
−20°C
Quality Level
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Application
从紫花丹中提取的白花丹素已用于：
- 作为活性氧试剂(ROS)在小鼠胚胎成纤维细胞中诱导细胞毒性
- 作为一种氧化应激诱导剂，在酿酒酵母中产生超氧阴离子
- 在雪花丹样品白花丹素含量测定的薄层色谱和分光光度分析中作为参考标准品
Biochem/physiol Actions
在癌症和啮齿动物癌症模型中表现出细胞毒性；具有抗真菌、抗病毒和抗菌作用。
白花丹素具有多种药理活性，包括抗菌、抗癌、抗动脉粥样硬化、抗糖尿病、抗炎、降血脂和神经保护活性。它可以抑制信号转导和转录激活因子3 (STAT3) 信号传导，阻止食管鳞状细胞癌 (ESCC) 的增殖。白花丹素在4-硝基喹啉-N-氧化物 (NQNO) 诱导的淋巴瘤应激中可诱导保护性抗氧化功能。纳米乳剂配方中的白花丹素对前列腺癌具有抗增殖作用。
General description
白花丹素是一种生物活性萘醌，主要存在于白花丹科植物紫雪花中。它是一种醌类化合物，也来源于白花丹的根。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
Kanjoormana Aryan Manu et al.
Molecular cancer, 10, 107-107 (2011-09-02)
Increasing evidence indicates that the interaction between the CXC chemokine receptor-4 (CXCR4) and its ligand CXCL12 is critical in the process of metastasis that accounts for more than 90% of cancer-related deaths. Thus, novel agents that can downregulate the CXCR4/CXCL12
Audrey Courboulin et al.
The European respiratory journal, 40(3), 618-629 (2012-04-13)
Like cancer, pulmonary arterial hypertension (PAH) is characterised by a pro-proliferative and anti-apoptotic phenotype. In PAH, pulmonary artery smooth muscle cell (PASMC) proliferation is enhanced and apoptosis suppressed. The sustainability of this phenotype requires the activation of pro-survival transcription factors
Yousef Alharbi et al.
Scientific reports, 9(1), 11471-11471 (2019-08-09)
The Na+/K+-ATPase (NKA) complex is the master regulator of membrane potential and a target for anti-cancer therapies. Here, we investigate the effect of drug-induced oxidative stress on NKA activity. The natural product, plumbagin increases oxygen radicals through inhibition of oxidative
Increased production of plumbagin in Plumbago indica root cultures by gamma ray irradiation
Jaisi A, et al.
Pharmaceutical biology, 51(8), 1047-1051 (2013)
Xiao-Juan Chen et al.
Saudi journal of biological sciences, 25(6), 1033-1039 (2018-09-04)
Cerebral ischemic damage and infarction are well documented in stroke, which is presenting a foremost health concern globally with very high mortality and morbidity rates. Mechanisms that are associated with excitotoxicity, inflammation and oxidative stress are found to be critically
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