P7265
前列腺素 A 1
≥98% (HPLC), powder, NF-κB inhibitor
别名:
(13E,15S)-15-羟基-9-氧代前列素-10,13-二烯-1-酸, PGA 1
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关于此项目
经验公式（希尔记法）:
C20H32O4
化学文摘社编号:
分子量:
336.47
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352211
MDL number:
Beilstein/REAXYS Number:
2003401
产品名称
前列腺素 A 1, synthetic
InChI key
BGKHCLZFGPIKKU-LDDQNKHRSA-N
SMILES string
O=C1[C@H](CCCCCCC(O)=O)[C@@H](/C=C/[C@H](CCCCC)O)C=C1
InChI
1S/C20H32O4/c1-2-3-6-9-17(21)14-12-16-13-15-19(22)18(16)10-7-4-5-8-11-20(23)24/h12-18,21H,2-11H2,1H3,(H,23,24)/b14-12+/t16-,17-,18+/m0/s1
biological source
synthetic
assay
≥98%
form
powder
storage temp.
−20°C
Quality Level
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相关类别
Biochem/physiol Actions
前列腺素A1（PGA1）是一种环戊酮前列腺素，含有化学反应性α,β-不饱和羰基。这种环氧合酶2（COX-2）代谢产物有助于调节阿尔茨海默病（AD）的发展和进展。此外，PGA1还通过迈克尔加成调控多种生物过程。它通过诱导受感染细胞的细胞保护性热激反应并抑制核因子-κB（NF-κB）活性，呈现禽流感病毒（IAV）的抗病毒活性。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Repr. 1B
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
A Aitokallio-Tallberg et al.
Cancer letters, 34(2), 201-206 (1987-02-01)
The production of the antiaggregatory and vasodilatory prostacyclin (PGI2) in patients with gynaecological tumours was studied by assaying urinary 6-keto-prostaglandin F1a (= 6-keto-PGF1a), a hydration product of PGI2), by radioimmunoassay following high performance liquid chromatography (HPLC) in 59 patients with
Beatriz Díez-Dacal et al.
Cancer research, 71(12), 4161-4171 (2011-04-22)
Cyclopentenone prostaglandins (cyPG) are reactive eicosanoids that may display anti-inflammatory and antiproliferative actions, possibly offering therapeutic potential. Here we report the identification of members of the aldo-keto reductase (AKR) family as selective targets of the cyPG prostaglandin A(1) (PGA(1)). AKR
Guo-Biao Xu et al.
Molecular neurobiology, 58(3), 1114-1127 (2020-10-24)
Prostaglandin (PG) A1 is a metabolic product of cyclooxygenase 2 (COX-2) that is potentially involved in regulating the development and progression of Alzheimer's disease (AD). PGA1 is a cyclopentenone (cy) PG characterized by the presence of a chemically reactive α,β-unsaturated
Stefania Carta et al.
Prostaglandins, leukotrienes, and essential fatty acids, 91(6), 311-323 (2014-08-26)
Influenza A viruses (IAV) have the potential to cause devastating pandemics. In recent years, the emergence of new avian strains able to infect humans represents a serious threat to global human health. The increase in drug-resistant IAV strains underscores the
M G Santoro
Experientia, 50(11-12), 1039-1047 (1994-11-30)
Acute infection of mammalian cells with several types of RNA and DNA viruses often results in induction of heat-shock gene expression. The presence of hsp70 in intact virions, as well as the transient association of HSP with viral proteins and
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