P7340
(±)-苏-1-苯基-2-癸酰氨基-3-吗啉-1-丙醇 盐酸盐
别名:
(±)-苏-PDMP 盐酸盐, PDMP 盐酸盐
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选择尺寸
关于此项目
经验公式（希尔记法）:
C23H38N2O3·HCl
化学文摘社编号:
分子量:
427.02
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C23H38N2O3.ClH/c1-2-3-4-5-6-7-11-14-22(26)24-21(19-25-15-17-28-18-16-25)23(27)20-12-9-8-10-13-20;/h8-10,12-13,21,23,27H,2-7,11,14-19H2,1H3,(H,24,26);1H/t21-,23-;/m1./s1
SMILES string
Cl.CCCCCCCCCC(=O)N[C@H](CN1CCOCC1)[C@H](O)c2ccccc2
InChI key
HVJHJOYQTSEKPK-BLDCTAJRSA-N
biological source
synthetic (organic)
assay
≥98% (TLC)
form
powder
solubility
water: 50 mg/mL, clear, colorless
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
葡萄糖神经酰胺合成酶抑制剂；阻止由神经酰胺形成葡萄糖基神经酰胺。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Jorge F Haller et al.
Journal of lipid research, 55(3), 493-503 (2013-12-03)
ABCA12 mutations disrupt the skin barrier and cause harlequin ichthyosis. We previously showed Abca12(-/-) skin has increased glucosylceramide (GlcCer) and correspondingly lower amounts of ceramide (Cer). To examine why loss of ABCA12 leads to accumulation of GlcCer, de novo sphingolipid
Radin, et al.
Journal of Lipid Research, 26, 183-213 (1993)
J Inokuchi et al.
Journal of cellular physiology, 141(3), 573-583 (1989-12-01)
Incubating B16 melanoma cells with an inhibitor of glucosylceramide (GlcCer) synthetase, D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (D-threo-PDMP), led to a considerable decrease in the levels of GlcCer and lactosylceramide (LacCer). The content of ganglioside GM3 was little affected, but the ability to bind a
A A Weber et al.
British journal of pharmacology, 123(5), 906-910 (1998-04-16)
1. The composition of glycosphingolipids is altered in atherosclerotic tissue. In order to study the possible modulation of interleukin-1beta (IL-1beta)-induced expression of inducible nitric oxide synthase (iNOS) by endogenously synthesized glycosphingolipids, we investigated rat aortic vascular smooth muscle cells (VSMC)
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