P7340
(±)-苏-1-苯基-2-癸酰氨基-3-吗啉-1-丙醇 盐酸盐
别名:
(±)-苏-PDMP 盐酸盐, PDMP 盐酸盐
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关于此项目
经验公式（希尔记法）:
C23H38N2O3·HCl
化学文摘社编号:
分子量:
427.02
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
biological source
synthetic (organic)
Quality Level
assay
≥98% (TLC)
form
powder
solubility
water: 50 mg/mL, clear, colorless
storage temp.
−20°C
SMILES string
Cl.CCCCCCCCCC(=O)N[C@H](CN1CCOCC1)[C@H](O)c2ccccc2
InChI
1S/C23H38N2O3.ClH/c1-2-3-4-5-6-7-11-14-22(26)24-21(19-25-15-17-28-18-16-25)23(27)20-12-9-8-10-13-20;/h8-10,12-13,21,23,27H,2-7,11,14-19H2,1H3,(H,24,26);1H/t21-,23-;/m1./s1
InChI key
HVJHJOYQTSEKPK-BLDCTAJRSA-N
Biochem/physiol Actions
葡萄糖神经酰胺合成酶抑制剂；阻止由神经酰胺形成葡萄糖基神经酰胺。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Radin, et al.
Journal of Lipid Research, 26, 183-213 (1993)
A A Weber et al.
British journal of pharmacology, 123(5), 906-910 (1998-04-16)
1. The composition of glycosphingolipids is altered in atherosclerotic tissue. In order to study the possible modulation of interleukin-1beta (IL-1beta)-induced expression of inducible nitric oxide synthase (iNOS) by endogenously synthesized glycosphingolipids, we investigated rat aortic vascular smooth muscle cells (VSMC)
J Inokuchi et al.
Journal of cellular physiology, 141(3), 573-583 (1989-12-01)
Incubating B16 melanoma cells with an inhibitor of glucosylceramide (GlcCer) synthetase, D-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (D-threo-PDMP), led to a considerable decrease in the levels of GlcCer and lactosylceramide (LacCer). The content of ganglioside GM3 was little affected, but the ability to bind a
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| P7340-100MG | 04061833220139 |