P7412
哌仑西平 二盐酸盐
≥98% (TLC), muscarinic acetylcholine receptor antagonist, powder
别名:
5,11-二氢-11-[（4-甲基-1-哌嗪基）乙酰基]-6H-吡啶[2,3-b][1,4]苯二氮卓-6-酮 二盐酸盐
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选择尺寸
关于此项目
经验公式（希尔记法）:
C19H21N5O2 · 2HCl
化学文摘社编号:
分子量:
424.32
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
249-907-5
MDL number:
产品名称
哌仑西平 二盐酸盐, ≥98% (TLC), powder
InChI key
FFNMBRCFFADNAO-UHFFFAOYSA-N
InChI
1S/C19H21N5O2.2ClH/c1-22-9-11-23(12-10-22)13-17(25)24-16-7-3-2-5-14(16)19(26)21-15-6-4-8-20-18(15)24;;/h2-8H,9-13H2,1H3,(H,21,26);2*1H
SMILES string
Cl[H].Cl[H].CN1CCN(CC1)CC(=O)N2c3ccccc3C(=O)Nc4cccnc24
assay
≥98% (TLC)
form
powder
color
white to light yellow
solubility
H2O: 50 mg/mL
Quality Level
Gene Information
human ... CHRM1(1128)
相关类别
Application
盐酸哌仑西平已用于
- 成纤维细胞生长因子受体（FGFR）的反式激活。
- 作为细胞培养的补充剂。
- 用于刺激人成纤维细胞
Biochem/physiol Actions
选择性M1毒蕈碱乙酰胆碱受体拮抗剂。
Disclaimer
吸湿性；在室温下干燥储存。
Features and Benefits
该化合物在受体分类和信号转导手册的 乙酰胆碱受体（毒蕈碱） 页面上有详细描述。想要浏览手册的其他页面， 请单击此处。
该化合物是神经科学研究推荐产品。点击此处 ，查看更多神经科学精选产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息，请访问 sigma.com/discover-bsm。
General description
盐酸哌仑西平是一种抗胆碱能药。它也被认为是抗溃疡药。用于治疗近视、胃及十二指肠溃疡。盐酸哌仑西平诱导毒蕈碱M1受体的二聚化。
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Pirenzepine promotes the dimerization of muscarinic M1 receptors through a three-step binding process
Ilien B, et al.
The Journal of Biological Chemistry, 13(6), jbc-M109 (2009)
Ion-paired pirenzepine-loaded micelles as an ophthalmic delivery system for the treatment of myopia
Li Y, et al.
Nanomedicine: Nanotechnology, Biology, and Medicine, 13(6), 2079-2089 (2017)
Mariko Iwase et al.
Biological & pharmaceutical bulletin, 40(10), 1654-1660 (2017-10-03)
OTC drugs have an important role in self-medication. However, the pharmacokinetic properties of some OTC drugs have not been fully investigated and reports concerning their drug interactions are insufficient. Several gastrointestinal drugs are available as OTC drugs. Because of their
Pirenzepine
Carmine AA and Brogden RN
Drugs, 30(2), 85-126 (1985)
Muscarinic acetylcholine type 1 receptor activity constrains neurite outgrowth by inhibiting microtubule polymerization and mitochondrial trafficking in adult sensory neurons
Sabbir MG, et al.
Frontiers in Neuroscience, 12(3), 229-237 (2018)
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