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P7527

前列腺素 E1

powder, γ-irradiated, BioXtra, suitable for cell culture

别名:

(11α,13E,15S)-11,15-二羟基-9-氧代前列-13-烯-1-酸, PGE1, 前列地尔

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关于此项目

经验公式（希尔记法）:
C20H34O5
化学文摘社编号:
745-65-3
分子量:
354.48
UNSPSC Code:
12352209
NACRES:
NA.77
PubChem Substance ID:
24898855
EC Number:
212-017-2
Beilstein/REAXYS Number:
5294062
MDL number:
MFCD00077860
eCl@ss:
42020658
Biological source:
synthetic (organic)
Form:
powder
Assay:
≥60% (HPLC)
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biological source

synthetic (organic)

Quality Level

200

sterility

γ-irradiated

product line

BioXtra

assay

≥60% (HPLC)

form

powder

concentration

≥60% (HPLC)

technique(s)

cell culture | mammalian: suitable

solubility

ethanol: 1 mg/mL

storage temp.

−20°C

SMILES string

O=C1[C@H](CCCCCCC(O)=O)[C@@H](/C=C/[C@H](CCCCC)O)[C@H](O)C1

InChI

1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h12-13,15-17,19,21,23H,2-11,14H2,1H3,(H,24,25)/b13-12+/t15-,16+,17+,19+/m0/s1

InChI key

GMVPRGQOIOIIMI-DWKJAMRDSA-N

Gene Information

human ... PTGER1(5731), PTGER2(5732), PTGIR(5739)
mouse ... Ptger1(19216), Ptger2(19217), Ptger3(19218), Ptger4(19219)

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相关类别

Application

前列腺素E1已用于维持小鼠近端小管和NRK-52E（一种大鼠肾上皮细胞系）。
用于细胞培养应用，可用于研究前列腺素调节的细胞信号转导和基因调控。

Biochem/physiol Actions

前列腺素介导血管舒张和血管收缩，前列腺素E系列是一种高效的血管舒张剂。它有效地引起红斑。前列腺素E1被认为是强效的致热因子，并通过脑室起作用。前列腺素E1可用于在手术前延长患有导管依赖型先天性心脏病的新生儿的心血管功能。

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000443120
0000443120
0000448003
0000448003
0000314222

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Long-term prostaglandin E1 infusion for newborns with critical congenital heart disease
Aykanat A, et al.
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Stephen A Davis et al.
Nature chemical biology, 11(7), 481-487 (2015-06-02)
Drugs that act more promiscuously provide fewer routes for the emergence of resistant mutants. This benefit, however, often comes at the cost of serious off-target and dose-limiting toxicities. The classic example is the antifungal amphotericin B (AmB), which has evaded
The Prostaglandins (2013)
Naturally produced crystals obtained from kidney stones are less injurious to renal tubular epithelial cells than synthetic crystals
Escobar C, et al.
BJU International, 100(4), 891-897 (2007)
Signe E Cremer et al.
PloS one, 14(11), e0224891-e0224891 (2019-11-14)
Domestic dogs share the same environment as humans, and they represent a valuable animal model to study naturally-occurring human disease. Platelet proteomics holds promise for the discovery of biomarkers that capture the contribution of platelets to the pathophysiology of many
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全球贸易项目编号

货号GTIN
P7527-10MG04061832315508
P7527-1MG04061834395294

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