P7547
酚妥拉明 盐酸盐
≥98% (TLC), α-adrenoceptor antagonist, powder
别名:
2-[N-（3-羟基苯基）-对-甲苯胺基甲基] -2-咪唑烷 盐酸盐, 3-[[（4,5-二氢-1H-咪唑-2-基）- 甲基]（4-甲基苯基）-氨基]-苯酚 单盐酸盐
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关于此项目
经验公式（希尔记法）:
C17H19N3O · HCl
化学文摘社编号:
分子量:
317.81
Beilstein:
3764617
EC 号:
MDL编号:
UNSPSC代码:
12352116
PubChem化学物质编号:
NACRES:
NA.77
产品名称
酚妥拉明 盐酸盐, ≥98% (TLC), powder
质量水平
方案
≥98% (TLC)
表单
powder
颜色
white to off-white
溶解性
ethanol: 14 mg/mL
H2O: 20 mg/mL
H2O: unstable (prepare immediately prior to use)
创始人
Novartis
SMILES字符串
Cl[H].Cc1ccc(cc1)N(CC2=NCCN2)c3cccc(O)c3
InChI
1S/C17H19N3O.ClH/c1-13-5-7-14(8-6-13)20(12-17-18-9-10-19-17)15-3-2-4-16(21)11-15;/h2-8,11,21H,9-10,12H2,1H3,(H,18,19);1H
InChI key
TUEJFGFQYKDAPM-UHFFFAOYSA-N
基因信息
human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152)
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相关类别
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
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Drug discoveries & therapeutics, 8(1), 11-17 (2014-03-22)
α1-Adrenergic receptors (α1-ARs), as one of the most important members of G protein-coupled receptors (GPCRs), can mediate lots of physiological responses of the sympathetic nervous system. Until now, α1-ARs have been divided into at least three subtypes, α1A, α1B, and
Kazuhisa Honda et al.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 163(3-4), 260-264 (2012-08-23)
We investigated the mechanism underlying central glucagon-induced hyperglycemia and anorexia in chicks. Male 8-day-old chicks (Gallus gallus) were used in all experiments. Intracerebroventricular administration of glucagon in chicks induced hyperglycemia and anorexia from 30 min after administration. However, the plasma
Zachary Barrett-O'Keefe et al.
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Aging is characterized by increased sympatho-excitation, expressed through both the α-adrenergic and RAAS (renin-angiotensin-aldosterone) pathways. Although the independent contribution of these two pathways to elevated vasoconstriction with age may be substantial, significant cross-talk exists that could produce potentiating effects. To
Kangbin Zhou et al.
Canadian journal of physiology and pharmacology, 90(8), 1075-1085 (2012-07-13)
Metabolic syndrome (MS) is a combination of medical disorders that increase the risk of developing cardiovascular disease and diabetes. MS is associated with obesity, increased blood pressure, hyperlipidemia, and hyperglycemia. This study was designed to investigate the pharmacological profile of
Ulrike Kuebler et al.
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