P7561
酚妥拉明 甲磺酸盐
≥98% (TLC), powder
别名:
2-(N-[m-羟基苯基]-p-甲苯氨基甲基)咪唑啉
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关于此项目
线性分子式:
C17H19N3O · CH3SO3H
化学文摘社编号:
分子量:
377.46
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352116
EC Number:
200-604-6
MDL number:
InChI
1S/C17H19N3O.CH4O3S/c1-13-5-7-14(8-6-13)20(12-17-18-9-10-19-17)15-3-2-4-16(21)11-15;1-5(2,3)4/h2-8,11,21H,9-10,12H2,1H3,(H,18,19);1H3,(H,2,3,4)
InChI key
OGIYDFVHFQEFKQ-UHFFFAOYSA-N
SMILES string
CS(O)(=O)=O.Cc1ccc(cc1)N(CC2=NCCN2)c3cccc(O)c3
assay
≥98% (TLC)
form
powder
color
white to off-white
mp
180-182 °C (lit.)
solubility
ethanol: 26 mg/mL, H2O: 50 mg/mL
originator
Novartis
Quality Level
Gene Information
human ... ADRA1A(148), ADRA1B(147), ADRA1D(146), ADRA2A(150), ADRA2B(151), ADRA2C(152)
Biochem/physiol Actions
α-肾上腺素受体拮抗剂；外周血管舒张剂。
Features and Benefits
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Darren P Casey et al.
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Aging is associated with increased retrograde and oscillatory shear in peripheral conduit arteries of humans. Although the mechanisms responsible for these age-related changes are not completely understood, augmented downstream α-adrenergic tone likely plays a significant role in this phenomenon. Therefore
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We investigated sex differences in cardiovascular maturation in embryos of the snapping turtle Chelydra serpentina, a species with temperature-dependent sex determination. One group of eggs was incubated at 26.5°C to produce males. Another group of eggs was incubated at 26.5°C
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Previous studies indicate epinephrine adversely affects arterial oxygenation when administered in a rat model of local anesthetic overdose. The authors tested whether epinephrine alone exerts similar effects in the intact animal. Anesthetized rats received a single intravenous injection of epinephrine
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