生物来源
synthetic
质量水平
检测方案
≥98.5% (GC)
形式
powder
mp
91-94 °C
溶解性
dry solvents (ethanol, methanol, and 2-propanol): 200 mM (Stock solution are stable for months at 4°C.)
H2O: unstable
SMILES string
FS(=O)(=O)Cc1ccccc1
InChI
1S/C7H7FO2S/c8-11(9,10)6-7-4-2-1-3-5-7/h1-5H,6H2
InChI key
YBYRMVIVWMBXKQ-UHFFFAOYSA-N
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一般描述
应用
PMSF的常见特性和优点包括：
- 抑制丝氨酸蛋白酶，如胰蛋白酶和胰凝乳蛋白酶
- 同时还可抑制半胱氨酸蛋白酶（通过还原硫醇可逆）和哺乳动物的乙酰胆碱酯酶
- 有效性和毒性均不及DFP
- 有效浓度0.1-1 mM。
- pH 7.5时半衰期 = 1小时。
- 细胞分级分离。
- 在核蛋白提取中作为补充剂。
- 胆固醇酯酶（CE）和假胆碱酯酶（PCE）抑制剂。
- 在离心之前用于血液的收集以量化血浆ANP的水平。
生化/生理作用
相关产品
警示用语：
Danger
危险声明
危险分类
Acute Tox. 3 Oral - Skin Corr. 1B
储存分类代码
6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
分析证书(COA)
输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。
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示例
其它示例：
705578-5MG-PW
PL860-CGA/SHF-1EA
MMYOMAG-74K-13
1000309185
输入内容 1.000309185)
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如何查找COA批号
批号可以在产品标签上"批“ （Lot或Batch）字后面找到。
Aldrich 产品
如果您查询到的批号为 TO09019TO 等，请输入去除前两位字母的批号：09019TO。
如果您查询到的批号含有填充代码（例如05427ES-021），请输入去除填充代码-021的批号：05427ES。
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部分情况下，可能未在线提供COA。如果搜索不到COA，可在线索取。
How should Product P7626, Phenylmethanesulfonyl fluoride (PMSF), solutions be prepared?
Stock solutions of 100-200 mM can be prepared in anhydrous isopropanol or anhydrous absolute ethanol. PMSF is unstable in the presence of water.
How should stock solutions of Product P7626, Phenylmethanesulfonyl fluoride (PMSF), be stored?
A 200 mM solution in dry solvent is stable for at least 9 months when stored at 2-8°C.
What does Product P7626, Phenylmethanesulfonyl fluoride (PMSF), inhibit?
PMSF is a serine protease inhibitor, inhibiting the activity of enzymes such as thrombin, trypsin, papain, chymotrypsin and proteinase K. It also inhibits mammalian acetylcholinesterases.
What is the effective amount of Product P7626, Phenylmethanesulfonyl fluoride (PMSF), to be used?
The effective concentration range is 0.1-1 mM. A final concentration of 5 mM was used for proteinase K inhibition.
Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
How do I find price and availability?
There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote. USA customers: 1-800-325-3010 or view local office numbers.
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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商品
Enzyme Explorer Product Application Index for Elastase. Leukocyte elastase is a 29KDa serine endoprotease of the Proteinase S1 Family. It exists as a single 238 amino acid-peptide chain with four disulfide bonds.
实验方案
Thrombin is an endolytic serine protease that selectively cleaves the Arg–Gly bonds of fibrinogen to form fibrin and release fibrinopeptides A and B.
凝血酶是一种内溶性丝氨酸蛋白酶，可选择性裂解纤维蛋白原的精氨酸-甘氨酸键，从而形成纤维蛋白并释放纤维蛋白肽A和B。
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