P7769
1,2-二酰- 锡 -甘油基-3-磷酸- L -丝氨酸
from bovine brain, ≥97% (TLC), amorphous powder, structural phospholipid
别名:
3-sn-Phosphatidyl-L-serine, L-α-磷脂酰-L-丝氨酸, PS, 磷脂酰丝氨酸
Application
1,2-二酰基-sn-甘油-3-磷酸-L-丝氨酸用于：
- 作为脂质标准品，用于飞行时间二次离子质谱（ToF-SIMS）谱指纹
- 作为参考标准品，用薄层色谱法（TLC）定量 ACM 处理成纤维细胞的脂质。（ACM：星形胶质细胞条件培养液）
- 作为单层大泡成分，用于研究膜联蛋白A2聚集。
Biochem/physiol Actions
1,2-二酰基-sn-甘油-3-磷酸-L-丝氨酸或磷脂酰丝氨酸（PS）是结构多样的酸性磷脂，在甘油sn位上存在脂肪酸酯。 基于牛脑皮质的PS是有效的脑营养物质。有利于神经传递，可能改善痴呆症患者的记忆情况。PS也是与核膜、髓磷脂、内质网、高尔基体和线粒体相关的主要膜磷脂。合成PS由磷脂酰丝氨酸合酶1催化，此酶通过内质网线粒体相关膜（MAM）结构域中的 L-丝氨酸和CDP-二酰基甘油合成。PS在吞噬过程中外部化，在肿瘤中失调，使其成为治疗靶标的潜在标志物。
一种主要发现于灰质中的代谢缓慢的结构磷脂。
Disclaimer
该溶液暴露在室温下每天会分解约 0.5%。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulation of the equilibrium between closed and open conformations of annexin A2 by N-terminal phosphorylation and S100A4-binding
Ecsedi P, et al.
Structure, 25(8), 1195-1207 (2017)
Formation and function of phosphatidylserine and phosphatidylethanolamine in mammalian cells
Vance JE and Tasseva G
Biochimica et biophysica acta. General subjects, 1831(3), 543-554 (2013)
Phosphatidylserine is a global immunosuppressive signal in efferocytosis, infectious disease, and cancer
Birge RB, et al.
Cell Death and Differentiation, 23(6), 962-962 (2016)
Thorsten Keller et al.
Molecular pharmacology, 95(2), 169-182 (2018-11-10)
Organic cation transporters OCT1 (SLC22A1) and OCT2 (SLC22A2) are critically involved in absorption and excretion of diverse cationic drugs. Because drug-drug interactions at these transporters may induce adverse drug effects in patients, in vitro testing during drug development for interaction
Comparison of molecular species of various transphosphatidylated phosphatidylserine (PS) with bovine cortex PS by mass spectrometry
Chen S and Li KW
Chemistry and Physics of Lipids, 152(1), 46-56 (2008)
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