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P8014

4α-佛波醇 12,13-二癸酸酯

Name: 4&#945;-佛波醇 12,13-二癸酸酯
Brand: SIGMA

transient receptor potential vanilloid 4 agonist, solid

别名:

4α-佛波醇 12-13-二癸酸酯, 4αPDD

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关于此项目

经验公式（希尔记法）:

C₄₀H₆₄O₈

化学文摘社编号:

27536-56-7

分子量:

672.93

NACRES:

NA.77

PubChem Substance ID:

24898900

UNSPSC Code:

12352211

MDL number:

MFCD00036737

Beilstein/REAXYS Number:

2514324

Form:

solid

Quality level:

100

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属性

产品名称

4α-佛波醇 12,13-二癸酸酯, solid

form

solid

Quality Level

100

color

white

solubility

DMSO: soluble, ethanol: soluble, methanol: soluble

storage temp.

−20°C

SMILES string

CCCCCCCCCC(=O)O[C@@H]1[C@@H](C)[C@@]2(O)C(C=C(CO)C[C@]3(O)C2C=C(C)C3=O)C4C(C)(C)[C@]14OC(=O)CCCCCCCCC

InChI

1S/C40H64O8/c1-7-9-11-13-15-17-19-21-32(42)47-36-28(4)39(46)30(24-29(26-41)25-38(45)31(39)23-27(3)35(38)44)34-37(5,6)40(34,36)48-33(43)22-20-18-16-14-12-10-8-2/h23-24,28,30-31,34,36,41,45-46H,7-22,25-26H2,1-6H3/t28-,30+,31-,34-,36-,38+,39-,40-/m1/s1

InChI key

DGOSGFYDFDYMCW-OEFRVDPMSA-N

说明

Application

4α-佛波醇12,13-二癸酸酯作为瞬时受体电位香草醛4(TRPV4)激动剂的应用实例：

研究其对Madin-Darby犬肾(MDCK)细胞的影响
研究其对小鼠输卵管细胞Ca²⁺内流的影响
研究其对小鼠足趾肿胀的影响

Biochem/physiol Actions

4α-佛波醇12,13-二癸酸酯是一种瞬时受体电位香草醛4(TRPV4)激动剂，可促进胞外钙离子内流进入细胞。

Preparation Note

不能使用水性介质制备储液；溶解于与水混溶的有机溶剂中，然后在水性介质中稀释至工作浓度。

Disclaimer

光敏性

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pictograms

GHS06,GHS08,GHS05

signalword

Danger

hcodes

H300 + H310 + H330,H314,H317,H334,H351

pcodes

P201 - P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 1 Dermal - Acute Tox. 1 Inhalation - Acute Tox. 2 Oral - Carc. 2 - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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