跳转至内容
Merck
CN

P8014

4α-佛波醇 12,13-二癸酸酯

transient receptor potential vanilloid 4 agonist, solid

别名:

4α-佛波醇 12-13-二癸酸酯, 4αPDD

登录 查看组织和合同定价。

选择尺寸

关于此项目

经验公式（希尔记法）:
C40H64O8
化学文摘社编号:
27536-56-7
分子量:
672.93
NACRES:
NA.77
PubChem Substance ID:
24898900
UNSPSC Code:
12352211
MDL number:
MFCD00036737
Beilstein/REAXYS Number:
2514324
Form:
solid
Quality level:
100

主要文件

查看所有文档
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助

产品名称

4α-佛波醇 12,13-二癸酸酯, solid

InChI

1S/C40H64O8/c1-7-9-11-13-15-17-19-21-32(42)47-36-28(4)39(46)30(24-29(26-41)25-38(45)31(39)23-27(3)35(38)44)34-37(5,6)40(34,36)48-33(43)22-20-18-16-14-12-10-8-2/h23-24,28,30-31,34,36,41,45-46H,7-22,25-26H2,1-6H3/t28-,30+,31-,34-,36-,38+,39-,40-/m1/s1

SMILES string

CCCCCCCCCC(=O)O[C@@H]1[C@@H](C)[C@@]2(O)C(C=C(CO)C[C@]3(O)C2C=C(C)C3=O)C4C(C)(C)[C@]14OC(=O)CCCCCCCCC

InChI key

DGOSGFYDFDYMCW-OEFRVDPMSA-N

form

solid

color

white

solubility

DMSO: soluble, ethanol: soluble, methanol: soluble

storage temp.

−20°C

Quality Level

100

正在寻找类似产品? 访问 产品对比指南

相关类别

Application

4α-佛波醇12,13-二癸酸酯作为瞬时受体电位香草醛4(TRPV4)激动剂的应用实例：
  • 研究其对Madin-Darby犬肾(MDCK)细胞的影响
  • 研究其对小鼠输卵管细胞Ca2+内流的影响
  • 研究其对小鼠足趾肿胀的影响

Biochem/physiol Actions

4α-佛波醇12,13-二癸酸酯是一种瞬时受体电位香草醛4(TRPV4)激动剂，可促进胞外钙离子内流进入细胞。

Disclaimer

光敏性

Preparation Note

不能使用水性介质制备储液；溶解于与水混溶的有机溶剂中，然后在水性介质中稀释至工作浓度。

signalword

Danger

Hazard Classifications

Acute Tox. 1 Dermal - Acute Tox. 1 Inhalation - Acute Tox. 2 Oral - Carc. 2 - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKCS9465
MKCR5246
MKCS0315
MKCP9077
MKCM2401

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Tumor-promoting activity of phorbol and four diesters of phorbol in mouse skin.
W M Baird et al.
Cancer research, 31(8), 1074-1079 (1971-08-01)
T A Rose-Hellekant et al.
Molecular reproduction and development, 44(2), 250-255 (1996-06-01)
The purpose of this investigation was to determine if precocious oocyte maturation could be induced by modulating ovarian cAMP-dependent protein kinase (PKA) or protein kinase C (PKC) signal transduction pathways in the intact hamster. The following inhibitors and stimulators were
Jennifer K Lee et al.
Journal of biomechanics, 47(15), 3712-3718 (2014-12-03)
Osteoarthritis, a degenerative disease of the load-bearing joints, greatly reduces quality of life for millions of Americans and places a tremendous cost on the American healthcare system. Due to limitations of current treatments, tissue engineering of articular cartilage may provide
Lei Chen et al.
Neuroscience letters, 452(1), 79-83 (2009-05-16)
The present study explored the effect of anisotonicity on action potential (AP) in cultured trigeminal ganglion (TG) neurons. We demonstrate that the number of evoked APs was increased by both hypo- and hypertonic treatment. Transient Receptor Potential Vanilloid 4 receptor
Y Fukushima et al.
The Biochemical journal, 320 ( Pt 1), 27-32 (1996-11-15)
The histamine H2 receptor is a member of the family of G-protein-coupled receptors and is linked to the activation of adenylate cyclase phospholipase C (PLC). In this study we examined the effects of protein kinase C (PKC) activation in Chinese
查看所有相关文献

商品

Carcinogenesis and Epigenetics

Cancer research has revealed that the classical model of carcinogenesis, a three step process consisting of initiation, promotion, and progression, is not complete.

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系客户支持