P8129
5β-Pregnan-3α-ol-20-one
synthetic (organic), ≥98% (TLC), γ-aminobutyric acid A receptors modulator, powder
别名:
3α-Hydroxy-5β-pregnan-20-one, 3α-Hydroxy-5β-tetrahydroprogesterone, Pregnanolone
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关于此项目
经验公式（希尔记法）:
C21H34O2
化学文摘社编号:
分子量:
318.49
UNSPSC Code:
12352202
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Biological source:
synthetic (organic)
Form:
powder
Assay:
≥98% (TLC)
产品名称
5β-Pregnan-3α-ol-20-one,
biological source
synthetic (organic)
Quality Segment
assay
≥98% (TLC)
form
powder
solubility
chloroform: 50 mg/mL, clear, colorless
shipped in
ambient
storage temp.
room temp
SMILES string
[H]C12CCC3C4CCC(C(C)=O)C4(C)CCC3C1(C)CC[C@H](O)C2
InChI
1S/C21H34O2/c1-13(22)17-6-7-18-16-5-4-14-12-15(23)8-10-20(14,2)19(16)9-11-21(17,18)3/h14-19,23H,4-12H2,1-3H3
InChI key
AURFZBICLPNKBZ-UHFFFAOYSA-N
Gene Information
rat ... Gabra2(29706)
Biochem/physiol Actions
5β-Pregnan-3α-ol-20-one or pregnanolone is a neurosteroid that acts as a positive allosteric modulator (PAMs) of γ-aminobutyric acid A receptors (GABAARs). It mediates anti-convulsive, anxiolytic and sedative effects. Pregnanolone inhibits γ-aminobutyric acid C receptor (GABAC) receptor-based response and favors GABAA receptor-mediated currents.
