P8477
Picotamide
别名:
4-Methoxy-N,N′-bis(3-pyridinylmethyl)-1,3-benzenedicarboxamide
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关于此项目
经验公式（希尔记法）:
C21H20N4O3
化学文摘社编号:
分子量:
376.41
EC 号:
MDL编号:
UNSPSC代码:
12352204
PubChem化学物质编号:
NACRES:
NA.83
方案
≥98%
表单
powder
溶解性
ethanol: 50 mg/mL, clear, colorless to light yellow
SMILES字符串
COc1ccc(cc1C(=O)NCc2cccnc2)C(=O)NCc3cccnc3
InChI
1S/C21H20N4O3/c1-28-19-7-6-17(20(26)24-13-15-4-2-8-22-11-15)10-18(19)21(27)25-14-16-5-3-9-23-12-16/h2-12H,13-14H2,1H3,(H,24,26)(H,25,27)
InChI key
KYWCWBXGRWWINE-UHFFFAOYSA-N
基因信息
human ... TBXA2R(6915)
生化/生理作用
Eicosenoid receptor antagonist; a thromboxane A2 antagonist; antiplatelet agent.
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Sergio Castellani et al.
Journal of the American College of Cardiology, 42(1), 133-139 (2003-07-10)
The aim of this study was to evaluate whether thromboxane inhibition can favorably affect renal perfusion and clinical conditions in patients affected by severe heart failure. The renal formation of the vasoconstrictor thromboxane A(2) (TxA(2)) is increased during cardiac failure.
S Basili et al.
Haematologica, 83(8), 701-707 (1998-10-30)
Prospective studies have shown that high plasma levels of fibrinogen are independently associated with the risk of cardiovascular complications. In patients suffering from peripheral vascular disease (PVD) fibrinogen has been shown to be an independent predictor of cardiovascular disease but
Gian Gastone Neri Serneri et al.
European heart journal, 25(20), 1845-1852 (2004-10-12)
Patients with diabetes are at excessive risk of mortality and cardiovascular morbidity. Previous studies suggest that aspirin may be less effective in diabetic patients. In this multi-centre, randomized, double blind trial picotamide, a dual inhibitor of thromboxane A2 synthase and
G Bettinetti et al.
Journal of pharmaceutical sciences, 88(11), 1133-1139 (1999-11-17)
Picotamide is an antiplatelet agent given by mouth as monohydrate (PICOW) (Plactidil) in thrombo-embolic disorders. This study deals with physical characterization of PICOW recrystallized from various solvents and the respective dehydration products using X-ray powder diffractometry (XRD), infrared spectroscopy (IR)
M Y Abeywardena et al.
Prostaglandins, leukotrienes, and essential fatty acids, 65(2), 91-97 (2001-09-08)
Two currently available edible oils-olive and canola-and two oil blends of plant origin having different n-3/n-6 polyunsaturated fatty acid (PUFA) ratios were evaluated for their ability to modify vascular dysfunction in the spontaneously hypertensive rat (SHR). Synthetic diets supplemented with
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