P8477
Picotamide
别名:
4-Methoxy-N,N′-bis(3-pyridinylmethyl)-1,3-benzenedicarboxamide
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C21H20N4O3
化学文摘社编号:
分子量:
376.41
NACRES:
NA.83
PubChem Substance ID:
UNSPSC Code:
12352204
EC Number:
251-245-7
MDL number:
InChI
1S/C21H20N4O3/c1-28-19-7-6-17(20(26)24-13-15-4-2-8-22-11-15)10-18(19)21(27)25-14-16-5-3-9-23-12-16/h2-12H,13-14H2,1H3,(H,24,26)(H,25,27)
InChI key
KYWCWBXGRWWINE-UHFFFAOYSA-N
SMILES string
COc1ccc(cc1C(=O)NCc2cccnc2)C(=O)NCc3cccnc3
assay
≥98%
form
powder
solubility
ethanol: 50 mg/mL, clear, colorless to light yellow
Quality Level
Gene Information
human ... TBXA2R(6915)
Biochem/physiol Actions
Eicosenoid receptor antagonist; a thromboxane A2 antagonist; antiplatelet agent.
存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Picotamide, an antithromboxane agent, inhibits the migration and proliferation of arterial myocytes.
S Ratti et al.
European journal of pharmacology, 355(1), 77-83 (1998-10-01)
Picotamide is an antiplatelet drug with a peculiar dual mechanism of action: it inhibits thromboxane A2 synthase and antagonizes the pharmacological responses mediated by thromboxane A2 receptor. We investigated the in vitro effect of picotamide on smooth muscle cell migration
Carola Buccellati et al.
European journal of pharmacology, 443(1-3), 133-141 (2002-06-05)
We evaluated the capacity of anti-aggregating agents to influence thromboxane A(2) and prostacyclin formation, arachidonic acid-endoperoxide redirection, platelet aggregation and vessel tone, in isolated rabbit aorta incubated with homologous platelets. Picotamide (N,N'bis(3-pyridinylmethyl)-4-methoxy-isophthalamide), the only dual thromboxane A(2)-synthase inhibitor/receptor antagonist in
R Vezza et al.
Thrombosis and haemostasis, 78(5), 1385-1391 (1998-01-04)
Picotamide is a dual thromboxane (Tx) A2 receptor antagonist/Tx synthase inhibitor although some observations suggest an anti-vasoconstrictor effect independent of TxA2 inhibition/antagonism. The aim of our study was to assess whether picotamide antagonises vascular contractions induced by different vasoactive substances
P Mura et al.
Drug development and industrial pharmacy, 24(8), 747-756 (1999-01-07)
The potential compatibilities of several commonly used pharmaceutical excipients with picotamide were evaluated using differential scanning calorimetry (DSC). The effects of aging and of mechanical treatment (blending, grinding, or kneading) of samples were also evaluated. Hot-stage microscopy (HSM) and scanning
M Berrettini et al.
European journal of clinical pharmacology, 39(5), 495-500 (1990-01-01)
Picotamide (G 137), a new non prostanoid inhibitor of in vitro arachidonic acid induced platelet aggregation, has been further characterized in in vitro and ex vivo studies. When whole blood was activated with collagen in the presence of picotamide 5
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持