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P8477

Picotamide

Name: Picotamide
Brand: SIGMA

别名:

4-Methoxy-N,N′-bis(3-pyridinylmethyl)-1,3-benzenedicarboxamide

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关于此项目

经验公式（希尔记法）:

C₂₁H₂₀N₄O₃

化学文摘社编号:

32828-81-2

分子量:

376.41

NACRES:

NA.83

PubChem Substance ID:

24278656

UNSPSC Code:

12352204

EC Number:

251-245-7

MDL number:

MFCD00866792

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assay

≥98%

Quality Level

100

form

powder

solubility

ethanol: 50 mg/mL, clear, colorless to light yellow

SMILES string

COc1ccc(cc1C(=O)NCc2cccnc2)C(=O)NCc3cccnc3

InChI

1S/C21H20N4O3/c1-28-19-7-6-17(20(26)24-13-15-4-2-8-22-11-15)10-18(19)21(27)25-14-16-5-3-9-23-12-16/h2-12H,13-14H2,1H3,(H,24,26)(H,25,27)

InChI key

KYWCWBXGRWWINE-UHFFFAOYSA-N

Gene Information

human ... TBXA2R(6915)

Biochem/physiol Actions

Eicosenoid receptor antagonist; a thromboxane A₂ antagonist; antiplatelet agent.

存储类别

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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Dietary polyunsaturated fatty acid and antioxidant modulation of vascular dysfunction in the spontaneously hypertensive rat.

M Y Abeywardena et al.

Prostaglandins, leukotrienes, and essential fatty acids, 65(2), 91-97 (2001-09-08)

Two currently available edible oils-olive and canola-and two oil blends of plant origin having different n-3/n-6 polyunsaturated fatty acid (PUFA) ratios were evaluated for their ability to modify vascular dysfunction in the spontaneously hypertensive rat (SHR). Synthetic diets supplemented with

Competitive inhibition of platelet thromboxane A2 receptor binding by picotamide.

P A Modesti et al.

European journal of pharmacology, 169(1), 85-93 (1989-10-04)

On the basis of indirect pharmacological evidence, picotamide, a methoxy derivative of 4-hydroxy-isophthalic acid (N,N'bis(3-picolyl)-4-methoxy-isophthalamide) has been postulated to inhibit platelet aggregation by competitively interfering with the thromboxane A2 (TxA2) platelet receptor. In the present study the interaction between picotamide

Long-term treatment with the dual antithromboxane agent picotamide decreases microalbuminuria in normotensive type 2 diabetic patients.

A Giustina et al.

Diabetes, 47(3), 423-430 (1998-03-31)

Picotamide both inhibits thromboxane synthetase and acts as a thromboxane antagonist at the receptor level. We investigated the long-term effect of picotamide on urinary albumin excretion (UAE) at rest and induced by exercise in 30 type 2 diabetic patients who

Physical characterization of picotamide monohydrate and anhydrous picotamide.

G Bettinetti et al.

Journal of pharmaceutical sciences, 88(11), 1133-1139 (1999-11-17)

Picotamide is an antiplatelet agent given by mouth as monohydrate (PICOW) (Plactidil) in thrombo-embolic disorders. This study deals with physical characterization of PICOW recrystallized from various solvents and the respective dehydration products using X-ray powder diffractometry (XRD), infrared spectroscopy (IR)

Thromboxane antagonism and cough induced by angiotensin-converting-enzyme inhibitor.

P L Malini et al.

Lancet (London, England), 350(9070), 15-18 (1997-07-05)

The increased prostaglandin synthesis that might follow stimulation of the arachidonic acid cascade by angiotensin-converting-enzyme inhibition (ACE-I) has been suggested to underlie the appearance of cough on ACE-I treatment. We investigated whether the prostanoid thromboxane was involved. Nine patients with

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全球贸易项目编号

货号	GTIN
P8477-5MG	04061833631461

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