P8624
Pirarubicin
≥95% (HPLC)
别名:
THP
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C32H37NO12
化学文摘社编号:
分子量:
627.64
MDL编号:
UNSPSC代码:
51281913
PubChem化学物质编号:
NACRES:
NA.85
质量水平
方案
≥95% (HPLC)
表单
powder
溶解性
ethanol: soluble 25 mg/mL
抗生素抗菌谱
neoplastics
作用机制
DNA synthesis | interferes
enzyme | inhibits
运输
wet ice
储存温度
2-8°C
SMILES字符串
COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](OC6CCCCO6)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO
InChI
1S/C32H37NO12/c1-14-31(45-21-8-3-4-9-42-21)17(33)10-22(43-14)44-19-12-32(40,20(35)13-34)11-16-24(19)30(39)26-25(28(16)37)27(36)15-6-5-7-18(41-2)23(15)29(26)38/h5-7,14,17,19,21-22,31,34,37,39-40H,3-4,8-13,33H2,1-2H3/t14-,17-,19-,21?,22-,31+,32-/m0/s1
InChI key
KMSKQZKKOZQFFG-NCXNULAVSA-N
应用
Pirarubicin is used to study synergistic cytotoxicity and apoptosis of cancer cells. It is used to study how to protect multi-drug resistance cells from anthracycline induced cytotoxicity.
生化/生理作用
Pirarubicin, an anthracycline antibiotic that is an analog of doxorubicin, is an antineoplastic drug. Pirarubicin is transported into cells via a sodium-dependent nucleoside transporter.1,2 It is used to intercalate DNA and inhibit the activity of topoisomerase II and induce DNA crosslinking.
包装
10mg,25mg
其他说明
Keep container tightly closed in a dry and well-ventilated place.
警示用语：
Danger
危险声明
危险分类
Carc. 1B - Muta. 1B - Repr. 1B
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
涉药品监管产品
此项目有
Romana J R Yanez et al.
PloS one, 12(8), e0183177-e0183177 (2017-08-12)
High-risk human papillomaviruses (hr-HPVs) cause cervical cancer, the fourth most common cancer in women worldwide. A HPV-16 candidate therapeutic vaccine, LALF32-51-E7, was developed by fusing a modified E7 protein to a bacterial cell-penetrating peptide (LALF): this elicited both tumour protection
Joaquim Carreras et al.
Histopathology, 70(4), 595-621 (2016-10-25)
We aimed to define the clinicopathological characteristics of 29 primary sinonasal diffuse large B cell lymphoma (DLBCL In the training set, 82% had a non-germinal center B-cell-like (Hans' Classifier) (non-GCB) phenotype and 18% were Epstein-Barr virus-encoded small RNAs (EBER) DLBCL
R Belhoussine et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 46(12), 1369-1376 (1998-11-17)
We used confocal microspectrofluorometry to investigate intracellular distribution of pirarubicin or THP-DOX in parental K562, CEM, and LR73 tumor cells and their corresponding multidrug-resistant (MDR) strains. Each spectrum of a recorded image was considered as a combination of cell autofluorescence
Matthieu Bourderioux et al.
Journal of proteome research, 14(1), 567-577 (2014-11-05)
Cystinuria is a purely renal, rare genetic disease caused by mutations in cystine transporter genes and characterized by defective cystine reabsorption leading to kidney stones. In 14% of cases, patients undergo nephrectomy, but given the difficulty to predict the evolution
Akihiro Ito et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 31(11), 1422-1427 (2013-03-06)
We evaluated the efficacy of a single early intravesical instillation of pirarubicin (THP) in the prevention of bladder recurrence after nephroureterectomy for upper urinary tract urothelial carcinoma (UUT-UC). From December 2005 to November 2008, 77 patients clinically diagnosed with UUT-UC
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持