产品名称
丙磺舒,
InChI key
DBABZHXKTCFAPX-UHFFFAOYSA-N
InChI
1S/C13H19NO4S/c1-3-9-14(10-4-2)19(17,18)12-7-5-11(6-8-12)13(15)16/h5-8H,3-4,9-10H2,1-2H3,(H,15,16)
SMILES string
CCCN(CCC)S(=O)(=O)c1ccc(cc1)C(O)=O
assay
≥98% (NaOH, titration)
originator
Merck & Co., Inc., Kenilworth, NJ, U.S.
Quality Level
Gene Information
human ... SLC22A11(55867), SLC22A6(9356), SLC22A8(9376)
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Application
丙磺舒已经用作:
- 无酚红Hank组分′细胞内Ca2+-转移试验的缓冲液
- 钙敏感染料组分,用于钙动员研究
- Hank′平衡盐溶液(HBSS)试验缓冲液补充剂
可用作有机阴离子转运蛋白MRP的抑制剂。
Biochem/physiol Actions
丙磺舒是尿酸排泄剂,可促进尿液尿酸排除,减少尿酸盐再摄取。它还能降低许多其他药物的肾小管分泌,提高药物血浆浓度。丙磺舒的抑制作用通过有机阴离子转运蛋白介导。已发现它可以用于治疗痛风。丙磺舒可防止神经化学物质从脉络丛和薄壁细胞移动至血浆,从而控制大脑内的神经化学物质水平上升。
Features and Benefits
该化合物是ADME Tox研究推荐产品。点击此处 ,查看更多ADME Tox精选产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息,请访问 sigma.com/discover-bsm。
该化合物由Merck & Co., Inc.(美国新泽西州Kenilworth)开发。想要浏览其他由制药公司开发的化合物以及已批准药物/候选药物清单, 请单击此处。
signalword
Warning
hcodes
pcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
监管及禁止进口产品
此项目有
The
Drugs of Abuse: Neurological Reviews and Protocols, 109-109 (2003)
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Probenecid, a gout remedy, inhibits pannexin 1 channels
Harris D, et al.
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Protein-based drug transporters are expressed in Sf9 cells. Understanding the specific mechanisms of tumor cell transporters is an essential aspect of chemotherapeutic drug design.
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