P8982
Anti-phospho-p53 (pSer392) antibody produced in rabbit
affinity isolated antibody, buffered aqueous glycerol solution
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关于此项目
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ARR, WB CL
Citations:
6
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous glycerol solution
mol wt
antigen 53 kDa
species reactivity
mouse, human
technique(s)
microarray: suitable, western blot (chemiluminescent): 1:1,000 using p53 fusion proteins with CKII phosphorylation or an extract of hydroxyurea-treated MvILu cells
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
phosphorylation (pSer392)
Quality Level
Gene Information
human ... TP53(7157)
mouse ... Trp53(22059)
General description
p53 is a tumor suppressor gene expressed in a wide variety of tissues. It is a tetrameric nuclear DNA-binding phosphoprotein. The gene encoding it is localized on human chromosome 17p13.1 and mouse chromosome 11.
Immunogen
synthetic peptide corresponding to residues around Ser392 of human p53 conjugated to KLH.
Biochem/physiol Actions
Does not react with non-phosphorylated p53.
Tumor suppressor p53 has the capability to induce cell cycle arrest and has a role in DNA repair, senescence and apoptosis. It binds to Simian vacuolating virus 40 (SV40) T-antigen and human papilloma virus E6 protein. The p53 gene is mutated in various cancers, such as of the breast, ovarian, bladder, colon and lung.
Physical form
Solution in 10 mM sodium HEPES, pH 7.5, containing 150 mM sodium chloride, 100 μg/ml bovine serum albumin and 50% glycerol
Preparation Note
Purified using protein A and peptide affinity chromatography.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
低风险生物材料
常规特殊物品
此项目有
Cell Cycle and Apoptosis
Bruna Pucci
Neoplasia, 2(4) (2000)
Cell Cycle and Apoptosis
Bruna Pucci
Neoplasia, 2(4) (2000)
Suppression of p53 potentiates chemosensitivity in nutrient?deprived cholangiocarcinoma cells via inhibition of autophagy
Fei Hui
Oncology, 14.2, 1959-1966 (2017)
Multiple myeloma involving central nervous system: high frequency of chromosome 17p13.1 (p53) deletions
Hong Chang
British Journal of Haematology, 127(3), 280?284-280?284 (2004)
Mutations in the p53 Tumor Suppressor Gene
Noa Rivlin
Genes & Cancer, 2(4), 466?474-466?474 (2011)
商品
p53 regulates gene expression, cell cycle control and functions as a tumor suppressor. Inactivation of p53 is closely tied to cancer development.
相关内容
Datasheet
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