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P9159

Piperidine-4-sulfonic acid

Name: Piperidine-4-sulfonic acid
Brand: SIGMA

别名:

P4S

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关于此项目

经验公式（希尔记法）:

C₅H₁₁NO₃S

化学文摘社编号:

72450-62-5

分子量:

165.21

NACRES:

NA.77

PubChem Substance ID:

24278165

UNSPSC Code:

12352106

MDL number:

MFCD00055097

Form:

powder

Quality level:

200

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form

powder

Quality Level

200

SMILES string

OS(=O)(=O)C1CCNCC1

InChI

1S/C5H11NO3S/c7-10(8,9)5-1-3-6-4-2-5/h5-6H,1-4H2,(H,7,8,9)

InChI key

UGBJGGRINDTHIH-UHFFFAOYSA-N

Gene Information

human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562)

Biochem/physiol Actions

GABA_A receptor agonist.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000379482

0000300095

0000234465

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The apparent voltage dependence of GABAA receptor activation and modulation is inversely related to channel open probability.

Kate K O'Toole et al.

Molecular pharmacology, 81(2), 189-197 (2011-11-02)

The GABA type A receptor (GABA(A)R) is expressed ubiquitously throughout the brain and is a target for many therapeutic agents, including general anesthetics and benzodiazepines, which enhance receptor function by increasing the open probability (P(o)) of the ion channel. It

Entropy as the predominant driving force of binding to human recombinant alpha(x)beta(3)gamma(2) GABA(A) receptors.

G Maksay et al.

European journal of pharmacology, 411(1-2), 55-60 (2001-01-04)

In order to study the correlation of the thermodynamic driving forces of binding with the efficacies of displacing ligands, the specific binding of [3H]SR 95531 [2-(3-carboxypropyl)3-amino-6-p-methoxyphenylpyridazinium bromide], a GABA(A) receptor antagonist, was studied in cell lines stably expressing human alpha(1)beta(3)gamma(2)

Molecular pharmacology of gamma-aminobutyric acid type A receptor agonists and partial agonists in oocytes injected with different alpha, beta, and gamma receptor subunit combinations.

B Ebert et al.

Molecular pharmacology, 46(5), 957-963 (1994-11-01)

Using systematic combination of alpha 1, alpha 3, and alpha 5 with beta 1, beta 2, and beta 3, together with gamma 1, gamma 2, and gamma 3, we have investigated the contributions of the various alpha, beta, and gamma

Pregnenolone sulfate block of GABA(A) receptors: mechanism and involvement of a residue in the M2 region of the alpha subunit.

G Akk et al.

The Journal of physiology, 532(Pt 3), 673-684 (2001-04-21)

Neurosteroids are produced in the brain, and can have rapid actions on membrane channels of neurons. Pregnenolone sulfate (PS) is a sulfated neurosteroid which reduces the responses of the [gamma]-aminobutyric acid A (GABA(A)) receptor. We analysed the actions of PS

The pre-M1 segment of the alpha1 subunit is a transduction element in the activation of the GABAA receptor.

Angelo Keramidas et al.

The Journal of physiology, 575(Pt 1), 11-22 (2006-06-10)

The binding of the neurotransmitter GABA induces conformational changes in the GABAA receptor (GABAAR), leading to the opening of a gate that controls ion permeation through an integral transmembrane pore. A number of structural elements within each subunit, located near

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全球贸易项目编号

货号	GTIN
P9159-250MG	04061832083704
P9159-25MG	04061832083711

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