P9689
丙戊茶碱
solid
别名:
3,7-二氢-3-甲基-1-(5-氧己基)-7-丙基-1H-嘌呤-2,6-二酮, 3-甲基-1-(5-氧己基)-7-丙基黄嘌呤, HWA 285
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选择尺寸
关于此项目
经验公式（希尔记法）:
C15H22N4O3
化学文摘社编号:
分子量:
306.36
MDL编号:
UNSPSC代码:
41106305
PubChem化学物质编号:
NACRES:
NA.77
表单
solid
颜色
white
溶解性
H2O: 12.4 mg/mL
储存温度
−20°C
SMILES字符串
CCCn1cnc2N(C)C(=O)N(CCCCC(C)=O)C(=O)c12
InChI
1S/C15H22N4O3/c1-4-8-18-10-16-13-12(18)14(21)19(15(22)17(13)3)9-6-5-7-11(2)20/h10H,4-9H2,1-3H3
InChI key
RBQOQRRFDPXAGN-UHFFFAOYSA-N
基因信息
human ... ADORA1(134), PRKAR1A(5573), PRKAR1AP(5574), PRKAR1B(5575), PRKAR2A(5576), PRKAR2B(5577)
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生化/生理作用
c-AMP 磷酸二酯酶抑制剂；神经生长因子刺激剂；腺苷转运抑制剂；非选择性腺苷受体拮抗剂。
特点和优势
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
警示用语：
Warning
危险分类
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
M Rother et al.
Annals of the New York Academy of Sciences, 777, 404-409 (1996-01-17)
The pharmacological profile of HWA 285 favors its use in patients with both Alzheimer's disease (PDD) and/or vascular dementia (MID). Clinical trials showed clinically relevant, statistically significant efficacy in the domains of cognitive function, global function and activities of daily
P Schubert et al.
Annals of the New York Academy of Sciences, 826, 337-347 (1997-11-05)
A pathological glial cell activation, which forces microglia to transform into immunocompetent cells with cytotoxic properties and astrocytes to "de-differentiate," presumably adds to neurodegenerative diseases. We examined the modulatory effect of adenosine on the Ca2+ and cAMP-dependent regulation of such
Xiaobo Wu et al.
Journal of neuroscience research, 90(6), 1270-1283 (2012-03-06)
Neuroadaptations in the nucleus accumbens (NAc) are associated with the development of drug addiction. Plasticity in synaptic strength and intrinsic excitability of NAc medium spiny neurons (MSNs) play critical roles in addiction induced by different classes of abused drugs. However
M Rother et al.
Dementia and geriatric cognitive disorders, 9 Suppl 1, 36-43 (1998-08-26)
Propentofylline, a neuroprotective glial cell modulator, has been shown in preclinical studies to address some of the common pathological processes of Alzheimer's disease (AD) and vascular dementia (VaD), including glial cell activation and increased production of cytokines, free radicals, and
R Mielke et al.
Alzheimer disease and associated disorders, 12 Suppl 2, S29-S35 (1998-10-13)
Pathophysiologic processes common to both vascular (multi-infarct) dementia and dementia of the Alzheimer type may include microglial activation with resultant generation of inflammatory cytokines and neurotoxic free radicals, decreased secretion of nerve growth factor by astrocytes, excess release of glutamate
商品
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
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