P9689
丙戊茶碱
solid
别名:
3,7-二氢-3-甲基-1-(5-氧己基)-7-丙基-1H-嘌呤-2,6-二酮, 3-甲基-1-(5-氧己基)-7-丙基黄嘌呤, HWA 285
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选择尺寸
关于此项目
经验公式（希尔记法）:
C15H22N4O3
化学文摘社编号:
分子量:
306.36
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
41106305
MDL number:
InChI
1S/C15H22N4O3/c1-4-8-18-10-16-13-12(18)14(21)19(15(22)17(13)3)9-6-5-7-11(2)20/h10H,4-9H2,1-3H3
SMILES string
CCCn1cnc2N(C)C(=O)N(CCCCC(C)=O)C(=O)c12
InChI key
RBQOQRRFDPXAGN-UHFFFAOYSA-N
form
solid
color
white
solubility
H2O: 12.4 mg/mL
storage temp.
−20°C
Quality Level
Gene Information
human ... ADORA1(134), PRKAR1A(5573), PRKAR1AP(5574), PRKAR1B(5575), PRKAR2A(5576), PRKAR2B(5577)
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Biochem/physiol Actions
c-AMP 磷酸二酯酶抑制剂；神经生长因子刺激剂；腺苷转运抑制剂；非选择性腺苷受体拮抗剂。
Features and Benefits
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
Russell P Landry et al.
Experimental neurology, 234(2), 340-350 (2011-11-29)
There is a growing body of preclinical evidence for the potential involvement of glial cells in neuropathic pain conditions. Several glial-targeted agents are in development for the treatment of pain conditions. Here we report the failure of a glial modulating
B Kittner et al.
Annals of the New York Academy of Sciences, 826, 307-316 (1997-11-05)
The mode of action of propentofylline (a xanthine derivative) suggested that it would have beneficial effects in patients with Alzheimer's disease or vascular dementia. In four double-blind, placebo-controlled, randomized studies, 901 patients with mild to moderate Alzheimer's disease and 359
Flávia V Santa-Cecília et al.
Pain, 160(1), 102-116 (2018-09-01)
Neuropathic pain is one of the most important types of chronic pain. It is caused by neuronal damage. Clinical and experimental studies suggest a critical role for neuroimmune interactions in the development of neuropathic pain. In this article, we have
Luis Constandil et al.
The journal of pain : official journal of the American Pain Society, 13(6), 579-589 (2012-05-09)
Several lines of evidence indicate that brain-derived neurotrophic factor (BDNF) plays a key role as a central pronociceptive modulator of pain, acting through postsynaptic TrkB receptors that trigger intracellular signaling cascades leading to central sensitization. The overall aim of this
Y S Gwak et al.
Neuroscience, 161(3), 895-903 (2009-04-01)
In this study, we evaluated whether astrocytic and microglial activation mediates below-level neuropathic pain following spinal cord injury. Male Sprague-Dawley (225-250 g) rats were given low thoracic (T13) spinal transverse hemisection and behavioral, electrophysiological and immunohistochemical methods were used to
商品
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
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