P9689
丙戊茶碱
solid
别名:
3,7-二氢-3-甲基-1-(5-氧己基)-7-丙基-1H-嘌呤-2,6-二酮, 3-甲基-1-(5-氧己基)-7-丙基黄嘌呤, HWA 285
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选择尺寸
关于此项目
经验公式（希尔记法）:
C15H22N4O3
化学文摘社编号:
分子量:
306.36
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
41106305
MDL number:
InChI
1S/C15H22N4O3/c1-4-8-18-10-16-13-12(18)14(21)19(15(22)17(13)3)9-6-5-7-11(2)20/h10H,4-9H2,1-3H3
SMILES string
CCCn1cnc2N(C)C(=O)N(CCCCC(C)=O)C(=O)c12
InChI key
RBQOQRRFDPXAGN-UHFFFAOYSA-N
form
solid
color
white
solubility
H2O: 12.4 mg/mL
storage temp.
−20°C
Quality Level
Gene Information
human ... ADORA1(134), PRKAR1A(5573), PRKAR1AP(5574), PRKAR1B(5575), PRKAR2A(5576), PRKAR2B(5577)
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Biochem/physiol Actions
c-AMP 磷酸二酯酶抑制剂；神经生长因子刺激剂；腺苷转运抑制剂；非选择性腺苷受体拮抗剂。
Features and Benefits
This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
此项目有
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Propentofylline: a nucleoside transport inhibitor with neuroprotective effects in cerebral ischemia.
F E Parkinson et al.
General pharmacology, 25(6), 1053-1058 (1994-10-01)
1. Adenosine is an endogenous neuroprotective agent; stimulation of A1 receptors decreases excitatory amino acid neurotransmission and stimulation of A2 receptors inhibits platelet and neutrophil activation and promotes vasodilation. 2. Post-ischemic administration of propentofylline (HWA 285) reduces neuronal damage in
A Nitta et al.
Behavioural brain research, 83(1-2), 201-204 (1997-02-01)
We have reported that the continuous infusion of anti-nerve growth factor (NGF) monoclonal antibody into the septum of rats produces an impairment of memory and a decrease in choline acetyltransferase (ChAT) and cholinesterase (ChE) activities in the hippocampus. Propentofylline, a
Y Fischer et al.
Journal of veterinary internal medicine, 25(6), 1270-1276 (2011-11-19)
Currently there is no drug proven to effectively treat cats with feline infectious peritonitis (FIP). Propentofylline (PPF) can decrease vasculitis, and therefore prolong survival time in cats with FIP, and increase their quality of life. Twenty-three privately owned cats with
Matthew S Alkaitis et al.
PloS one, 5(5), e10891-e10891 (2010-06-10)
An alarming portion of patients develop persistent or chronic pain following surgical procedures, but the mechanisms underlying the transition from acute to chronic pain states are not fully understood. In general, endocannabinoids (ECBs) inhibit nociceptive processing by stimulating cannabinoid receptors
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Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
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