P9797
溴吡斯的明
≥98% (HPLC), Acetylcholinesterase inhibitor, solid
别名:
3-(Dimethylaminocarbonyloxy)-1-methylpyridinium bromide
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关于此项目
经验公式（希尔记法）:
C9H13BrN2O2
化学文摘社编号:
分子量:
261.12
EC 号:
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
产品名称
溴吡斯的明,
方案
≥98% (HPLC)
质量水平
表单
solid
溶解性
water: 100 mg/mL, clear to very slightly hazy, colorless
创始人
Valeant
SMILES字符串
[Br-].CN(C)C(=O)Oc1ccc[n+](C)c1
InChI
1S/C9H13N2O2.BrH/c1-10(2)9(12)13-8-5-4-6-11(3)7-8;/h4-7H,1-3H3;1H/q+1;/p-1
InChI key
VNYBTNPBYXSMOO-UHFFFAOYSA-M
基因信息
human ... ACHE(43)
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应用
Pyridostigmine bromide has been used as a cholinesterase inhibitor in mice, in florimetric assay for acetylcholine secretion and for measuring acetylcholine release from mice atrial tissue.
生化/生理作用
Acetylcholinesterase inhibitor.
Pyridostigmine bromide inhibits acetylcholine esterase and is membrane impermeable. It is used as a preventive medicine in chemical warfare. Pyridostigmine bromide is a carbamate compound comprising quaternary amine structure. It displays low absorption at the gastrointestinal tract. Sustained release of pyridostigmine is recommended for improving its bioavailability in treating myasthenia gravis.
特点和优势
This compound was developed by Valeant. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
警示用语：
Danger
危险分类
Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral - Skin Sens. 1
储存分类代码
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
法规信息
新产品
此项目有
Gulf War and health Depleted uranium, pyridostigmine bromide, sarin, and vaccines (2000)
Cardiomyocyte-secreted acetylcholine is required for maintenance of homeostasis in the heart
Roy A, et al.
Faseb Journal, 27(12), 5072-5082 (2013)
Cardiac acetylcholine inhibits ventricular remodeling and dysfunction under pathologic conditions
Roy A, et al.
Faseb Journal, 30(2), 688-701 (2015)
Renske I Wadman et al.
Neurology, 79(20), 2050-2055 (2012-11-02)
Spinal muscular atrophy (SMA) is pathologically characterized by degeneration of anterior horn cells. Recent observations in animal models of SMA and muscle tissue from patients with SMA suggest additional abnormalities in the development and maturation of the neuromuscular junction. We
H Zach et al.
European journal of neurology, 20(4), 708-713 (2013-01-03)
Several small retrospective studies have observed that patients with a purely ocular manifestation of myasthenia gravis (MG) are significantly less likely to convert to a generalized disease when treated early on with corticosteroids. However, given the limited number of reported
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