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主要文件

安全信息

P9797

Sigma-Aldrich

溴吡斯的明

别名:

3-(Dimethylaminocarbonyloxy)-1-methylpyridinium bromide

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About This Item

经验公式(希尔记法):
C9H13BrN2O2
CAS Number:
分子量:
261.12
EC 号:
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77

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方案

≥98% (HPLC)

质量水平

表单

solid

溶解性

water: 100 mg/mL, clear to very slightly hazy, colorless

创始人

Valeant

SMILES字符串

[Br-].CN(C)C(=O)Oc1ccc[n+](C)c1

InChI

1S/C9H13N2O2.BrH/c1-10(2)9(12)13-8-5-4-6-11(3)7-8;/h4-7H,1-3H3;1H/q+1;/p-1

InChI key

VNYBTNPBYXSMOO-UHFFFAOYSA-M

基因信息

human ... ACHE(43)

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此商品
PHR3120S8502A5879
form

solid

form

-

form

powder

form

powder

assay

≥98% (HPLC)

assay

-

assay

≥98% (HPLC)

assay

≥98% (TLC)

Quality Level

100

Quality Level

300

Quality Level

200

Quality Level

100

solubility

water: 100 mg/mL, clear to very slightly hazy, colorless

solubility

-

solubility

H2O: 50 mg/mL

solubility

water: 50 mg/mL, clear to very slightly hazy, colorless to yellow

originator

Valeant

originator

-

originator

-

originator

-

Gene Information

human ... ACHE(43)

Gene Information

-

Gene Information

human ... CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133)

Gene Information

human ... NOS1(4842), NOS2(4843), NOS2B(201288), NOS2C(645740), NOS3(4846)

应用

Pyridostigmine bromide has been used as a cholinesterase inhibitor in mice,[1] in florimetric assay for acetylcholine secretion[2] and for measuring acetylcholine release from mice atrial tissue.[3]

生化/生理作用

Acetylcholinesterase inhibitor.
Pyridostigmine bromide inhibits acetylcholine esterase and is membrane impermeable. It is used as a preventive medicine in chemical warfare.[4] Pyridostigmine bromide is a carbamate compound comprising quaternary amine structure. It displays low absorption at the gastrointestinal tract.[5] Sustained release of pyridostigmine is recommended for improving its bioavailability in treating myasthenia gravis.[6]

特点和优势

This compound was developed by Valeant. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

象形图

Skull and crossbones

警示用语:

Danger

危险分类

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral - Skin Sens. 1

储存分类代码

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

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    分析证书(COA)

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    Cardiac acetylcholine inhibits ventricular remodeling and dysfunction under pathologic conditions
    Roy A, et al.
    Faseb Journal, 30(2), 688-701 (2015)
    Gulf War and health Depleted uranium, pyridostigmine bromide, sarin, and vaccines (2000)
    Cardiomyocyte-secreted acetylcholine is required for maintenance of homeostasis in the heart
    Roy A, et al.
    Faseb Journal, 27(12), 5072-5082 (2013)
    Benefits from sustained-release pyridostigmine bromide in myasthenia gravis: results of a prospective multicenter open-label trial
    Sieb JP and Kohler W
    Clinical Neurology and Neurosurgery, 112(9), 781-784 (2010)
    Preparation and in vitro evaluation of pyridostigmine bromide microparticles
    Hegazy N, et al.
    International Journal of Pharmaceutics, 242(1-2), 171-174 (2002)

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